CAS No. 1142363-52-7

Batch: Purity:99.75
Check CoA
Edicotinib(JNJ-40346527) Chemical Structure
Chemical Structure
Check the Edicotinib(JNJ-40346527) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 5-cyano-N-[2-(4,4-dimethylcyclohexen-1-yl)-6-(2,2,6,6-tetramethyloxan-4-yl)-3-pyridinyl]-1H-imidazole-2-carboxamide
CAS Number 1142363-52-7
Molecular Formula

C27H35N5O2
Molecular Weight (MW) 461.6
SMILES CC1(C)CCC(=CC1)C2=NC(=CC=C2NC(=O)C3=NC=C([NH]3)C#N)C4CC(C)(C)OC(C)(C)C4
InChIKey BNVPFDRNGHMRJS-UHFFFAOYSA-N

Biological Activity

Edicotinib (JNJ-40346527) is an orally active and brain-penetrant inhibitor of colony-stimulating factor-1 receptor (CSF-1R) with an IC50 of 3.2 nM. By blocking CSF-1R kinase activity, it suppresses downstream signaling pathways essential for macrophage and microglial survival, proliferation, and differentiation. Consequently, CSF-1R inhibition reduces neuroinflammatory responses and decreases myeloid cell accumulation in cellular and tissue models.

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 92 mg/mL (199.3 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 92 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.