CAS No. 27220-47-9
Batch:
Purity:99.97
Chemical Structure
Check the
Econazole
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole | |
|---|---|---|
| CAS Number | 27220-47-9 | |
| Molecular Formula |
C18H15Cl3N2O |
|
| Molecular Weight (MW) | 381.68 | |
| SMILES | C1=CC(=CC=C1COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl)Cl | |
| InChIKey | LEZWWPYKPKIXLL-UHFFFAOYSA-N |
Biological Activity
Econazole is a broad-spectrum imidazole antimycotic agent that inhibits fungal lanosterol 14α-demethylase. By blocking this enzyme, econazole suppresses ergosterol biosynthesis, leading to structural and functional disruption of fungal cell membranes and inhibition of fungal growth. In addition to its primary antifungal properties, econazole exhibits antibacterial action against select Gram-positive bacteria.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
76 mg/mL
(199.11 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Note: Technical data last updated: Sep 1, 2026.