CAS No. 1914078-41-3

Batch: Purity:99.99
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eCF506 Chemical Structure
Chemical Structure
Check the eCF506 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name tert-butyl N-[4-[4-amino-1-[2-[4-(dimethylamino)piperidin-1-yl]ethyl]pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl]carbamate
CAS Number 1914078-41-3
Molecular Formula

C26H38N8O3
Molecular Weight (MW) 510.63
SMILES CC(C)(C)OC(=O)NC1=C(C=C(C=C1)C2=NN(C3=NC=NC(=C23)N)CCN4CCC(CC4)N(C)C)OC
InChIKey GMPQGWXPDRNCBL-UHFFFAOYSA-N

Biological Activity

eCF506 is a potent, selective, and orally bioavailable inhibitor of Src tyrosine kinase (IC50 <. By selectively binding to the inactive conformation of Src, eCF506 blocks Src autophosphorylation and suppresses downstream Src-mediated signaling pathways. Consequently, this inhibition leads to the impairment of cancer cell proliferation, survival, and migratory capacity without cross-reacting with Abl kinase. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Ethanol 100 mg/mL
DMSO 30 mg/mL (58.75 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Fraser C, et al. J Med Chem. 2016;59(10):4697-710.

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Note: Technical data last updated: Sep 1, 2026.