CAS No. 2320427-95-8

Batch: Purity:99.80
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EAD1 Chemical Structure
Chemical Structure
Check the EAD1 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[[1-[(4-chlorophenyl)methyl]triazol-4-yl]methyl]-N'-[2-[(7-chloroquinolin-4-yl)amino]ethyl]-N'-methylethane-1,2-diamine;2,2,2-trifluoroacetic acid
CAS Number 2320427-95-8
Molecular Formula

C26H28Cl2F3N7O2
Molecular Weight (MW) 598.45
SMILES CN(CCNCC1=C[N](CC2=CC=C(Cl)C=C2)N=N1)CCNC3=CC=NC4=CC(=CC=C34)Cl.OC(=O)C(F)(F)F
InChIKey LZSPLENCPSTSGU-UHFFFAOYSA-N

Biological Activity

EAD1 is a small-molecule autophagy inhibitor with antiproliferative activity against cancer cells. By inhibiting autophagic flux, EAD1 disrupts cellular homeostasis and essential turnover pathways required for tumor cell survival. This impairment of autophagy leads to reduced growth and suppression of proliferation in both lung cancer and pancreatic cancer cells, highlighting its potential utility in targeting autophagy-dependent malignancies. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (167.09 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 100 mg/mL
Ethanol 100 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Levy JMM, et al. Nat Rev Cancer. 2017;17(9):528-542.

[2] Amaravadi RK, et al. Clin Cancer Res. 2011;17(4):654-66.

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Note: Technical data last updated: Sep 1, 2026.