CAS No. 1140964-99-3

Batch: Purity:98.29
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Stenoparib (E7449) Chemical Structure
Chemical Structure
Check the Stenoparib (E7449) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 11-(1,3-dihydroisoindol-2-ylmethyl)-2,3,10,12-tetrazatricyclo[7.3.1.05,13]trideca-1,5(13),6,8,11-pentaen-4-one
CAS Number 1140964-99-3
Molecular Formula

C18H15N5O
Molecular Weight (MW) 317.34
SMILES C1C2=CC=CC=C2CN1CC3=NC4=NNC(=O)C5=C4C(=CC=C5)N3
InChIKey JLFSBHQQXIAQEC-UHFFFAOYSA-N

Ordering Information

Biological Activity

Stenoparib (E7449) is an orally bioavailable, brain-penetrable small-molecule dual inhibitor targeting PARP1 (IC50 = 1.0 nM) and PARP2 (IC50 = 1.2 nM), while also inhibiting tankyrase 1 and 2 (TNKS1/2, PARP5a/5b). Through dual inhibition of PARP enzyme activity and tankyrase signaling, Stenoparib disrupts DNA repair mechanisms and modulates canonical Wnt/β-catenin pathway activity. These molecular actions lead to suppressed cellular proliferation and reduced tumor growth in DNA repair-deficient cancer models.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 4 mg/mL (12.6 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.