CAS No. 552325-73-2
Batch:
Purity:99.71
Chemical Structure
Check the
A-674563
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (2S)-1-[[5-(3-methyl-2H-indazol-5-yl)-3-pyridinyl]oxy]-3-phenylpropan-2-amine | |
|---|---|---|
| CAS Number | 552325-73-2 | |
| Molecular Formula |
C22H22N4O |
|
| Molecular Weight (MW) | 358.44 | |
| InChIKey | BPNUQXPIQBZCMR-IBGZPJMESA-N |
A-674563 is an orally active Akt kinase inhibitor that selectively targets Akt1, as well as PKA and CDK2. By inhibiting Akt activity and reducing downstream substrate phosphorylation, the compound suppresses signaling through the AKT/mTOR and associated oncogenic pathways. This pathway blockade impairs downstream cell cycle progression and cellular growth, ultimately leading to the inhibition of tumor cell proliferation and reduced cancer cell survival. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
72 mg/mL
(200.87 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 72 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.