CAS No. 1219925-73-1
Batch:
Purity:99.32
Chemical Structure
Check the
E6446
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 6-(3-pyrrolidin-1-ylpropoxy)-2-[4-(3-pyrrolidin-1-ylpropoxy)phenyl]-1,3-benzoxazole | |
|---|---|---|
| CAS Number | 1219925-73-1 | |
| Molecular Formula |
C27H35N3O3 |
|
| Molecular Weight (MW) | 449.59 | |
| SMILES | C1CCN(C1)CCCOC2=CC=C(C=C2)C3=NC4=C(O3)C=C(C=C4)OCCCN5CCCC5 | |
| InChIKey | YMYJXFUPMPMETB-UHFFFAOYSA-N |
E6446 is a potent inhibitor of Toll-like receptor 7 (TLR7) and Toll-like receptor 9 (TLR9) signaling. It directly interferes with nucleic acid binding by disrupting DNA-TLR9 interactions and blocking endosomal receptor activation. By suppressing downstream TLR7 and TLR9 pathways, E6446 attenuates NF-kB activation and proinflammatory cytokine production in various human and murine immune cell types, demonstrating significant immunomodulatory activity.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Ethanol | 90 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.