CAS No. 751475-53-3
Batch:
Purity:99.14
Chemical Structure
Check the
Atopaxar
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 751475-53-3 | |
|---|---|---|
| Molecular Formula |
C29H38FN3O5 |
|
| Molecular Weight (MW) | 527.63 | |
| SMILES | CCOC1=C(C(=C2C(=C1)CN(C2=N)CC(=O)C3=CC(=C(C(=C3)N4CCOCC4)OC)C(C)(C)C)F)OCC |
Atopaxar (E5555) is a potent, orally active, selective, and reversible antagonist of protease-activated receptor-1 (PAR-1). By selectively blocking PAR-1 signaling, Atopaxar inhibits thrombin-induced intracellular calcium mobilization and suppresses downstream platelet activation and aggregation. This pathway inhibition prevents arterial thrombosis and attenuates vascular inflammatory responses without altering normal coagulation cascades or systemic hemostasis mediated through independent target receptors. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Ethanol | 100 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.