CAS No. 65576-45-6
Batch:
Purity:98.67
Chemical Structure
Check the
Asenapine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 65576-45-6 | |
|---|---|---|
| Molecular Formula |
C17H16ClNO |
|
| Molecular Weight (MW) | 285.77 |
Asenapine is a multi-target receptor antagonist targeting serotonin receptors (pKi 8.4–10.5), adrenoceptors (pKi 8.9–9.5), dopamine receptors (pKi 8.9–9.4), and histamine receptors (pKi 8.2–9.0). High-affinity blockade of these G-protein–coupled receptors regulates central monoaminergic neurotransmission pathways, impacting downstream dopaminergic and serotonergic intracellular signaling cascades. In preclinical animal models, asenapine modulates neurotransmitter release and demonstrates potent antipsychotic and pro-cognitive behavioral phenotypes.
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
57 mg/mL
(199.46 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 57 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.