CAS No. 1031195-19-3
Batch:
Purity:99.865
Chemical Structure
Check the
E1231
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 1031195-19-3 | |
|---|---|---|
| Molecular Formula |
C21H21N3O3 |
|
| Molecular Weight (MW) | 363.41 |
E1231 is a piperazine 1,4-diamide derivative that acts as an orally active activator of sirtuin 1 (SIRT1). Targeting SIRT1 stimulates cellular signaling pathways that increase macrophage cholesterol efflux and decrease intracellular lipid accumulation. These actions regulate systemic cholesterol and lipid metabolism, demonstrating potential therapeutic application for the treatment of atherosclerosis in hyperlipidemic models. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
73 mg/mL
(200.87 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 73 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.