CAS No. 936339-60-5

Batch: Purity:99.98
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Manogepix (E1210) Chemical Structure
Chemical Structure
Check the Manogepix (E1210) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 3-[3-[[4-(pyridin-2-yloxymethyl)phenyl]methyl]-1,2-oxazol-5-yl]pyridin-2-amine
CAS Number 936339-60-5
Molecular Formula

C21H18N4O2
Molecular Weight (MW) 358.39
SMILES C1=CC=NC(=C1)OCC2=CC=C(C=C2)CC3=NOC(=C3)C4=C(N=CC=C4)N
InChIKey WSEKTEUGRLFBSE-UHFFFAOYSA-N

Biological Activity

Manogepix (E1210) is a broad-spectrum, orally active antifungal agent that targets fungal Gwt1 (glycosylphosphatidylinositol-anchored wall transfer protein 1). By inhibiting Gwt1, it selectively blocks inositol acylation within the glycosylphosphatidylinositol anchor biosynthesis pathway. This inhibition disrupts cell wall mannoprotein trafficking and anchoring, impairing fungal cell wall integrity and compromising cell adherence and biofilm formation. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 72 mg/mL (200.89 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 20 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Watanabe T, et al. Antimicrob Agents Chemother. 2012;56(7):3657-63.

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Note: Technical data last updated: Sep 1, 2026.