CAS No. 3367-88-2

Batch: Purity:99.39
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(E/Z)-GSK-3β inhibitor 1 Chemical Structure
Chemical Structure
Check the (E/Z)-GSK-3β inhibitor 1 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (3Z)-3-(pyridin-2-ylmethylidene)-1H-indol-2-one
CAS Number 3367-88-2
Molecular Formula

C14H10N2O
Molecular Weight (MW) 222.24
SMILES O=C1NC2=CC=CC=C2/C1=C/C3=CC=CC=N3
InChIKey YKQONSWBHGBDSB-XFXZXTDPSA-N

Ordering Information

Biological Activity

(E/Z)-GSK-3β inhibitor 1 is a 3-substituted 2-oxindole inhibitor of glycogen synthase kinase 3β (GSK-3β) with an IC50 of 4.19 nM. By inhibiting GSK-3β kinase activity, it modulates downstream metabolic and oncogenic signaling pathways. In cellular and preclinical models, this inhibition results in moderate cytotoxicity against A549 cancer cells and improved glucose tolerance in obese diabetic rats. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 44 mg/mL (197.98 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 3 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.