CAS No. 2370013-49-1

Batch: Purity:99.76
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(S)-Sunvozertinib ((S)-DZD9008) Chemical Structure
Chemical Structure
Check the (S)-Sunvozertinib ((S)-DZD9008) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[5-[[4-[5-chloro-4-fluoro-2-(2-hydroxypropan-2-yl)anilino]pyrimidin-2-yl]amino]-2-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl]prop-2-enamide
CAS Number 2370013-49-1
Molecular Formula

C29H35ClFN7O3
Molecular Weight (MW) 584.08
SMILES COC1=C(NC2=NC=CC(=N2)NC3=CC(=C(F)C=C3C(C)(C)O)Cl)C=C(NC(=O)C=C)C(=C1)N4CCC(C4)N(C)C
InChIKey BTMKEDDEMKKSEF-KRWDZBQOSA-N

Ordering Information

Biological Activity

(S)-Sunvozertinib ((S)-DZD9008) is an oral, potent, irreversible, wild-type-selective inhibitor of epidermal growth factor receptor (EGFR) targeting mutant EGFR and HER2 exon 20 insertion mutations. In preclinical models, sunvozertinib selectively suppresses EGFR autophosphorylation and downstream signaling through the AKT/mTOR and MAPK/ERK pathways. This targeted inhibition reduces cellular proliferation and promotes apoptosis in non-small cell lung cancer models harboring exon 20 insertions while sparing wild-type EGFR. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (171.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 25 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.