CAS No. 95167-41-2

Batch: Purity:99.96
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DY131 Chemical Structure
Chemical Structure
Check the DY131 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 95167-41-2
Molecular Formula

C18H21N3O2
Molecular Weight (MW) 311.38
SMILES CCN(CC)C1=CC=C(C=C1)C=NNC(=O)C2=CC=C(C=C2)O

Biological Activity

DY131 is a selective agonist of estrogen-related receptors beta (ERRβ) and gamma (ERRγ), displaying no significant activity against ERRα or estrogen receptors ERα and ERβ. Through selective ERRβ/γ activation, the compound regulates downstream nuclear receptor transcriptional networks involved in metabolic homeostasis and energy regulation. Modulating these receptor pathways subsequently influences cellular proliferation and metabolic phenotypes in target cell models. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 62 mg/mL (199.11 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] GiguéreV. Trends in Endocrinology & Metabolism. 2002;13(5):220-225.

[2] Giguère V. Endocr Rev. 2008;29(6):677-96.

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Note: Technical data last updated: Sep 1, 2026.