CAS No. 88149-94-4
Batch:
Purity:99.43
Chemical Structure
Check the
DuP-697
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 5-bromo-2-(4-fluorophenyl)-3-(4-methylsulfonylphenyl)thiophene | |
|---|---|---|
| CAS Number | 88149-94-4 | |
| Molecular Formula |
C17H12BrFO2S2 |
|
| Molecular Weight (MW) | 411.31 | |
| InChIKey | AJFTZWGGHJXZOB-UHFFFAOYSA-N |
Biological Activity
DuP-697 is a potent, irreversible, selective, and orally active inhibitor of cyclooxygenase-2 (COX-2). By suppressing COX-2 enzymatic activity, DuP-697 blocks downstream prostaglandin synthesis and attenuates pro-inflammatory signaling pathways. In cancer cells, targeted COX-2 inhibition exerts antiproliferative, antiangiogenic, and pro-apoptotic effects by inducing cell-cycle arrest and activating caspase cascades to suppress cellular growth.[1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
82 mg/mL
(199.36 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 4 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
Jump to
Note: Technical data last updated: Sep 1, 2026.