CAS No. 130288-24-3
Chemical Structure
Check the
Duocarmycin SA
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | methyl (1R,12S)-7-oxo-10-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-5,10-diazatetracyclo[7.4.0.01,12.02,6]trideca-2(6),3,8-triene-4-carboxylate | |
|---|---|---|
| CAS Number | 130288-24-3 | |
| Molecular Formula | ||
| InChIKey | VQNATVDKACXKTF-XELLLNAOSA-N |
Biological Activity
Duocarmycin SA is a potent antitumor antibiotic and DNA-alkylating agent with an IC50 of 10 pM. It induces sequence-selective alkylation of duplex DNA, disrupting cellular DNA replication and transcription processes. This DNA damage leads to cell cycle arrest and potent cytotoxic effects against cancer cells, supporting its investigation in glioblastoma multiforme research. [1]
Solubility
Reference
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Note: Technical data last updated: Sep 1, 2026.