CAS No. 116539-59-4
Batch:
Purity:99.91
Chemical Structure
Check the
Duloxetine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (3S)-N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-ylpropan-1-amine | |
|---|---|---|
| CAS Number | 116539-59-4 | |
| Molecular Formula |
C18H19NOS |
|
| Molecular Weight (MW) | 297.41 | |
| SMILES | CNCCC(C1=CC=CS1)OC2=CC=CC3=CC=CC=C32 | |
| InChIKey | ZEUITGRIYCTCEM-KRWDZBQOSA-N |
Duloxetine (LY-248686) is a dual serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor that preferentially inhibits 5-HT uptake over NE uptake in vitro and in vivo. By blocking serotonin and norepinephrine transporters, duloxetine elevates extracellular neurotransmitter concentrations in monoaminergic pathways. This inhibition modulates downstream monoaminergic neurotransmission and central pain pathways, producing antinociceptive and antidepressant-like behavioral phenotypes in animal models. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
59 mg/mL
(198.37 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 59 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.