CAS No. 136434-34-9
Batch:
Purity:99.89
Chemical Structure
Check the
Duloxetine HCl
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | (3S)-N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-ylpropan-1-amine;hydrochloride | |
|---|---|---|
| CAS Number | 136434-34-9 | |
| Molecular Formula |
C18H19NOS.HCl |
|
| Molecular Weight (MW) | 333.88 | |
| SMILES | CNCCC(C1=CC=CS1)OC2=CC=CC3=CC=CC=C32.Cl | |
| InChIKey | BFFSMCNJSOPUAY-LMOVPXPDSA-N |
Biological Activity
Duloxetine HCl is a serotonin-norepinephrine reuptake inhibitor that potently blocks serotonin uptake and norepinephrine uptake. By inhibiting neurotransmitter reuptake at presynaptic monoamine transporters, it increases synaptic levels of serotonin and norepinephrine. This accumulation enhances central serotonergic and noradrenergic neurotransmission, thereby modulating downstream signaling pathways involved in neuronal excitability and nociceptive signaling. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
67 mg/mL
(200.67 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 3 mg/mL |
| Ethanol | Insoluble |
| DMSO |
67 mg/mL
(200.67 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 6 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
Jump to
Note: Technical data last updated: Sep 1, 2026.