CAS No. 1809427-19-7

Batch: Purity:99.95
Check CoA
DT-061 (SMAP) Chemical Structure
Chemical Structure
Check the DT-061 (SMAP) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 1809427-19-7
Molecular Formula

C25H23F3N2O5S
Molecular Weight (MW) 520.52
SMILES C1CC(C(C(C1)N2C3=CC=CC=C3OC4=CC=CC=C42)O)NS(=O)(=O)C5=CC=C(C=C5)OC(F)(F)F

Biological Activity

DT-061 (SMAP) is an orally bioavailable small-molecule activator of protein phosphatase 2A (PP2A). By stabilizing specific PP2A heterotrimers, it promotes the dephosphorylation and degradation of key oncogenic drivers, including c-Myc and AKT. This activation impairs downstream AKT/mTOR and MAPK signaling cascades, thereby suppressing cell proliferation, decreasing cell viability in non-small cell lung cancer models, and inducing apoptosis in cancer cells. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (192.11 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 50 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Free Aliquotting Service

Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.

Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.

Reference

[1] Sangodkar J, et al. J Clin Invest. 2017;127(6):2081-2090.

[2] Leonard D, et al. Cell. 2020;181(3):688-701.e16.

Jump to

Note: Technical data last updated: Sep 1, 2026.