CAS No. 58142-99-7
Batch:
Purity:97.5
Chemical Structure
Check the
DSRM-3716
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5-iodoisoquinoline | |
|---|---|---|
| CAS Number | 58142-99-7 | |
| Molecular Formula |
C9H6IN |
|
| Molecular Weight (MW) | 255.06 | |
| InChIKey | CUILFTFMBBGSFT-UHFFFAOYSA-N |
DSRM--Iodoisoquinoline) is a potent and selective inhibitor of sterile alpha and Toll/interleukin-1 receptor motif-containing protein 1 (SARM1) with an IC0 of 7. By inhibiting SARM1 NADase enzymatic activity, it prevents cyclic ADP-ribose (cADPR) elevation and axonal NAD+ depletion following axotomy or mitochondrial stress. This preserves cellular energy metabolism and robustly blocks pathological axonal degeneration. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
51 mg/mL
(199.95 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 51 mg/mL |
| Water | 3 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.