CAS No. 2512197-69-0
Batch:
Purity:99.34
Chemical Structure
Check the
DSP5336
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (2R)-2-[[3-cyclobutyl-5-(3,4,5-trifluorophenoxy)imidazo[4,5-b]pyridin-2-yl]methylamino]propanamide | |
|---|---|---|
| CAS Number | 2512197-69-0 | |
| Molecular Formula |
C20H20F3N5O2 |
|
| Molecular Weight (MW) | 419.40 | |
| InChIKey | HHXCJIMPEJSJTG-SNVBAGLBSA-N |
DSP5336 is an oral small-molecule inhibitor of the menin and MLL protein-protein interaction. Disruption of the menin-MLL complex impairs oncogenic transcriptional programs driven by MLL rearrangements or NPM1 mutations, downregulating downstream leukemogenic targets including HOXA9 and MEIS1. Consequently, inhibition of this transcriptional axis suppresses cellular proliferation and induces differentiation and apoptosis in susceptible acute leukemia cells. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
84 mg/mL
(200.28 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 84 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.