CAS No. 57757-57-0
Chemical Structure
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DSP Crosslinker
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Chemical Information
| IUPAC Name | (2,5-dioxopyrrolidin-1-yl) 3-[[3-(2,5-dioxopyrrolidin-1-yl)oxy-3-oxopropyl]disulfanyl]propanoate | |
|---|---|---|
| CAS Number | 57757-57-0 | |
| Molecular Formula |
C14H16N2O8S2 |
|
| Molecular Weight (MW) | 404.42 | |
| SMILES | C1CC(=O)N(C1=O)OC(=O)CCSSCCC(=O)ON2C(=O)CCC2=O | |
| InChIKey | FXYPGCIGRDZWNR-UHFFFAOYSA-N |
Biological Activity
DSP Crosslinker is a homobifunctional, amine-reactive, thiol-cleavable crosslinking agent widely utilized in antibody-drug conjugate (ADC) synthesis and protein structure analysis. The molecule features two reactive N-hydroxysuccinimide (NHS) ester groups that covalently target primary amines on protein substrates, while its central disulfide spacer enables reversible reductive cleavage under thiol-reducing conditions, facilitating characterization of protein-protein interactions and bioconjugate functional assembly.
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Note: Technical data last updated: Sep 1, 2026.