CAS No. 1505515-69-4
Batch:
Purity:99.98
Chemical Structure
Check the
Taletrectinib (DS-6051b)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3-[4-[(2R)-2-aminopropoxy]phenyl]-N-[(1R)-1-(3-fluorophenyl)ethyl]imidazo[1,2-b]pyridazin-6-amine;hexanedioic acid | |
|---|---|---|
| CAS Number | 1505515-69-4 | |
| Molecular Formula |
C29H34FN5O5 |
|
| Molecular Weight (MW) | 551.61 | |
| SMILES | CC(COC1=CC=C(C=C1)C2=CN=C3N2N=C(C=C3)NC(C)C4=CC(=CC=C4)F)N.C(CCC(=O)O)CC(=O)O | |
| InChIKey | DORJQZDOULKINH-QNBGGDODSA-N |
Taletrectinib (DS-6051b) is a potent, selective ROS1 and NTRK inhibitor targeting ROS1 (IC50 =, NTRK1 (IC50 =, NTRK2 (IC50 =, and NTRK3 (IC50 =. By suppressing ROS1 and TRK receptor tyrosine kinase phosphorylation, it blocks downstream MAPK/ERK and AKT/mTOR signaling pathways, resulting in the inhibition of cellular proliferation and the induction of apoptosis in ROS1- and NTRK-driven cancer models. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
50 mg/mL
(90.64 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Taletrectinib (DS-6051b) Clinical Trials
- Taletrectinib (DS-6051b) Solubility in DMSO
- Taletrectinib (DS-6051b) Stock Solution
- Taletrectinib (DS-6051b) Storage
- Taletrectinib (DS-6051b) Stability
- Taletrectinib (DS-6051b) Molecular Weight
- Taletrectinib (DS-6051b) SMILES
- Taletrectinib (DS-6051b) Chemical Structure (2D and 3D)
- Taletrectinib (DS-6051b) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.