CAS No. 548-66-3

Batch: Purity:98
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Drofenine Hydrochloride Chemical Structure
Chemical Structure
Check the Drofenine Hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-(diethylamino)ethyl 2-cyclohexyl-2-phenylacetate;hydrochloride
CAS Number 548-66-3
Molecular Formula

C20H32ClNO2
Molecular Weight (MW) 353.93
SMILES CCN(CC)CCOC(=O)C(C1CCCCC1)C2=CC=CC=C2.Cl
InChIKey WIELVDXKOYPANK-UHFFFAOYSA-N

Ordering Information

Biological Activity

Drofenine hydrochloride is an anticholinergic agent and a competitive inhibitor of butyrylcholinesterase (BChE). By antagonizing muscarinic receptors and selectively inhibiting BChE activity, it modulates cholinergic neurotransmission and suppresses smooth muscle spasms. This dual activity impairs acetylcholine-mediated signaling pathways, resulting in antispasmodic effects at both the neuronal level and directly within smooth muscle fibers. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
1 mg 5 mg 10 mg
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 71 mg/mL (200.6 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.