CAS No. 129075-73-6
Batch:
Purity:98.92
Chemical Structure
Check the
DPQ
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5-(4-piperidin-1-ylbutoxy)-3,4-dihydro-2H-isoquinolin-1-one | |
|---|---|---|
| CAS Number | 129075-73-6 | |
| Molecular Formula |
C18H26N2O2 |
|
| Molecular Weight (MW) | 302.41 | |
| InChIKey | RVOUDNBEIXGHJY-UHFFFAOYSA-N |
DPQ is a potent inhibitor of poly(ADP-ribose) polymerase 1 (PARP1). By inhibiting PARP1, DPQ suppresses macrophage-mediated inflammatory responses and mitigates acute lung injury induced by lipopolysaccharide challenge in mice. Mechanistically, DPQ blocks the NF-κB signaling pathway by inhibiting IκB-α phosphorylation and degradation, leading to reduced vascular permeability, decreased neutrophil infiltration, lower myeloperoxidase activity, and suppressed pro-inflammatory cytokine production. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
60 mg/mL
(198.4 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 60 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.