CAS No. 484049-04-9
Batch:
Purity:99.03
Chemical Structure
Check the
DPH
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 484049-04-9 | |
|---|---|---|
| Molecular Formula |
C18H13FN4O2 |
|
| Molecular Weight (MW) | 336.32 |
DPH is a cell-permeable small-molecule activator of c-Abl tyrosine kinase with an ECof. It binds directly to the c-Abl myristoyl binding pocket, preventing autoinhibitory conformation and promoting c-Abl kinase activation. This activation stimulates c-Abl autophosphorylation at Yand Yand enhances downstream substrate phosphorylation, such as Crk-L phosphorylation, thereby regulating Abl tyrosine kinase-dependent cellular signaling pathways. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
67 mg/mL
(199.21 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 6 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.