CAS No. 23214-92-8

Batch: Purity:99.71
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Doxorubicin Chemical Structure
Chemical Structure
Check the Doxorubicin product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (7S,9S)-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione
CAS Number 23214-92-8
Molecular Formula

C27H29NO11
Molecular Weight (MW) 543.52
SMILES COC1=C2C(=O)C3=C(C(=C4CC(O)(CC(OC5CC(N)C(O)C(C)O5)C4=C3O)C(=O)CO)O)C(=O)C2=CC=C1
InChIKey AOJJSUZBOXZQNB-TZSSRYMLSA-N

Biological Activity

Doxorubicin (Adriamycin) is an anthracycline antibiotic chemotherapy agent that inhibits human DNA topoisomerase II with an IC50 of 2.67 μM. By targeting DNA topoisomerase II, doxorubicin blocks essential topological turnover, causing DNA replication arrest and strand accumulation. This inhibition disrupts cell cycle progression, suppresses cancer cell growth across multiple tumor types, and induces programmed cell death via apoptotic pathways. [1]

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (183.98 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 100 mg/mL
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Rhee HK, et al. Bioorg Med Chem. 2007;15(4):1651-8.

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Note: Technical data last updated: Sep 1, 2026.