Doxorubicin (Adriamycin) Hydrochloride Mechanism of Action: Topoisomerase II beta Inhibition in Cardiomyocyte Research

Doxorubicin (Adriamycin) Hydrochloride MOA：Targeting Topoisomerase II beta/ROS Signaling Pathway for Cardiotoxicity Mitigation and Mechanisms

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Doxorubicin (Adriamycin) Hydrochloride is a potent, non-selective DNA and Topoisomerase II inhibitor. It affects p53, cGAS-STING, and MAPK signaling pathways by intercalating into DNA and inducing double-strand breaks, promoting apoptosis and immunogenic cell death.

Primary Applications and Mechanism of Action

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