CAS No. 3094-09-5

Batch: Purity:99.76
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Doxifluridine Chemical Structure
Chemical Structure
Check the Doxifluridine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 3094-09-5
Molecular Formula

C9H11FN2O5
Molecular Weight (MW) 246.19
SMILES CC1C(C(C(O1)N2C=C(C(=O)NC2=O)F)O)O

Biological Activity

Doxifluridine is a fluoropyrimidine derivative and an oral prodrug of the cytotoxic agent 5-fluorouracil (5-FU). It is selectively activated to 5-FU by thymidine phosphorylase, leading to the inhibition of thymidylate synthase and the incorporation of fluorinated metabolites into RNA and DNA. Consequently, doxifluridine disrupts nucleic acid synthesis, triggers DNA damage, and selectively suppresses tumor cell proliferation. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 49 mg/mL (199.03 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 49 mg/mL
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Respiratory Care. 1980;25(10):1075-1075.

[2] Armstrong RD, et al. Cancer Res. 1980;40(9):3333-8.

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Note: Technical data last updated: Sep 1, 2026.