CAS No. 1285572-51-1

Batch: Purity:99.59
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Dotinurad (FYU-981) Chemical Structure
Chemical Structure
Check the Dotinurad (FYU-981) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (3,5-dichloro-4-hydroxyphenyl)-(1,1-dioxo-2H-1,3-benzothiazol-3-yl)methanone
CAS Number 1285572-51-1
Molecular Formula

C14H9Cl2NO4S
Molecular Weight (MW) 358.2
SMILES OC1=C(Cl)C=C(C=C1Cl)C(=O)N2C[S;v6](=O)(=O)C3=CC=CC=C23
InChIKey VOFLAIHEELWYGO-UHFFFAOYSA-N

Biological Activity

Dotinurad (FYU- is a selective urate reabsorption inhibitor that potently inhibits urate transporter 1 (URAT1) with an IC50 of. By blocking URAT1-mediated urate transport in renal proximal tubule cells, dotinurad suppresses renal uric acid reabsorption. This targeted inhibition increases fractional excretion of urate and effectively lowers plasma uric acid levels in vivo. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 72 mg/mL (201.0 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Taniguchi T, et al. J Pharmacol Exp Ther. 2019;371(1):162-170.

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Note: Technical data last updated: Sep 1, 2026.