CAS No. 132172-61-3
Batch:
Purity:99.57
Chemical Structure
Check the
DOTAP chloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2,3-bis[[(Z)-octadec-9-enoyl]oxy]propyl-trimethylazanium chloride | |
|---|---|---|
| CAS Number | 132172-61-3 | |
| Molecular Formula |
C42H80ClNO4 |
|
| Molecular Weight (MW) | 698.54 | |
| SMILES | [Cl-].CCCCCCCC\C=C/CCCCCCCC(=O)OCC(C[N+](C)(C)C)OC(=O)CCCCCCC\C=C/CCCCCCCC | |
| InChIKey | KSXTUUUQYQYKCR-LQDDAWAPSA-M |
DOTAP chloride is a cationic lipid widely utilized as a liposomal transfection reagent and an activator of the innate immune system. It facilitates efficient cellular delivery of nucleic acids and proteins while stimulating immune responses by triggering intracellular signaling pathways and inducing pro-inflammatory cytokine expression. Additionally, DOTAP serves as an effective adjuvant and a promising elicitor for investigating plant immune mechanisms. [1][2]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(143.15 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.