CAS No. 285983-48-4
Batch:
Purity:99.99
Chemical Structure
Check the
Doramapimod (BIRB 796)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-[3-tert-butyl-1-(4-methylphenyl)pyrazol-5-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea | |
|---|---|---|
| CAS Number | 285983-48-4 | |
| Molecular Formula |
C31H37N5O3 |
|
| Molecular Weight (MW) | 527.66 | |
| SMILES | CC1=CC=C(C=C1)N2C(=CC(=N2)C(C)(C)C)NC(=O)NC3=CC=C(C4=CC=CC=C43)OCCN5CCOCC5 | |
| InChIKey | MVCOAUNKQVWQHZ-UHFFFAOYSA-N |
Doramapimod (BIRB 796) is a potent, cell-permeable pan-p38 MAPK inhibitor that binds p38α with a Kd of. It targets all p38 MAPK isoforms, effectively blocking the p38 MAPK pathway and downstream phosphorylation of Hsp27. Through this inhibition, Doramapimod suppresses pro-inflammatory cytokine production and impairs cell proliferation, demonstrating potential anti-inflammatory and chemo-sensitizing effects in cellular models. [1][2]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(189.51 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(189.51 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(189.51 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
| DMSO |
106 mg/mL
(200.88 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 106 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(189.51 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Doramapimod (BIRB 796) Clinical Trials
- Doramapimod (BIRB 796) Solubility in DMSO
- Doramapimod (BIRB 796) Stock Solution
- Doramapimod (BIRB 796) Storage
- Doramapimod (BIRB 796) Stability
- Doramapimod (BIRB 796) Molecular Weight
- Doramapimod (BIRB 796) SMILES
- Doramapimod (BIRB 796) Chemical Structure (2D and 3D)
- Doramapimod (BIRB 796) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.