Clinical Trials

Numerous clinical trials investigate dopamine's therapeutic utility and physiological role across diverse indications, ranging from cardiovascular and hemodynamic disorders to neurodevelopmental and psychiatric conditions. Spanning Early Phase 1 through Phase 4, these studies encompass completed, actively recruiting, terminated, and withdrawn protocols evaluating applications such as surgical dopamine infusions and cortical imaging. Research across this landscape is sponsored by major academic institutions and public research agencies, including the National Institute on Drug Abuse, the National Institute of Mental Health, and Samsung Medical Center.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT07559500 RECRUITING
Alcohol Use Disorder (AUD)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
 2026-05-20 PHASE1
NCT07562932 NOT_YET_RECRUITING
Cardiogenic Shock
Chonnam National University Hospital
 2026-05-31
NCT07151378 RECRUITING
PARKINSON DISEASE (Disorder)
University Hospital Tuebingen
 2025-10-27 PHASE3
NCT07793461 NOT_YET_RECRUITING
Parkinson's Disease
Beth Israel Deaconess Medical Center
 2027-07 PHASE4
NCT07663474 RECRUITING
Addiction; SMARTPHONE OWNER
Pusan National University Hospital
 2026-05-01
NCT07045935 RECRUITING
Prolactinoma
University Hospital, Basel, Switzerland
 2025-09-16 PHASE4
NCT06977308 NOT_YET_RECRUITING
Clinical High Risk for Psychosis (CHR)
New York State Psychiatric Institute
 2026-10-01 PHASE1
NCT06477744 ACTIVE_NOT_RECRUITING
Parkinson's Disease
S.Biomedics Co., Ltd.
 2023-09-14
NCT07252752 NOT_YET_RECRUITING
First Episode Psychosis (FEP)
Medical University of Vienna
 2026-01-01
NCT07667829 NOT_YET_RECRUITING
Pulmonary Arterial Hypertension (PAH); Chronic Thromboembolic Pulmonary Hypertension (CTEPH); Hypertension, Pulmonary
China National Center for Cardiovascular Diseases
 2026-06
NCT06369623 RECRUITING
Adolescent Development
Stony Brook University
 2024-04-06
NCT06583291 NOT_YET_RECRUITING
Parkinson Disease
Anhui Provincial Hospital
 2024-10-01 EARLY_PHASE1
NCT07111442 NOT_YET_RECRUITING
Renal Artery Stenosis Atherosclerotic; Secondary Hypertension Renal Arterial
Peking University First Hospital
 2025-08-30
NCT07572071 RECRUITING
Parkinson Disease (PD)
Royan Institute
 2025-08-01 PHASE1
NCT07386080 NOT_YET_RECRUITING
Scizophrenia
Zealand University Hospital
 2026-05-01 PHASE4
NCT06284382 RECRUITING
Trauma, Psychological
Hôpital le Vinatier
 2026-04-27
NCT07166757 RECRUITING
Parkinson Disease (PD)
XellSmart Bio-Pharmaceutical (Suzhou) Co., Ltd.
 2025-09-22 PHASE1; PHASE2
NCT07732426 RECRUITING
Food Addiction Tendency; Obesity; Overweight
Seoul National University Hospital
 2026-07-15
NCT05901818 RECRUITING
Parkinson's Disease
Xuanwu Hospital, Beijing
 2021-04-01 PHASE1
NCT06482268 RECRUITING
PD - Parkinson's Disease
University of California, San Diego
 2024-06-01 PHASE1
NCT05285683 RECRUITING
Chronic Pain
University of Rochester
 2024-01-31 PHASE2
NCT07212088 NOT_YET_RECRUITING
Parkinson Disease
iCamuno Biotherapeutics Ltd.
 2026-02-28 PHASE1
NCT06687837 RECRUITING
Parkinson Disease
Jeffrey S. Schweitzer, MD, PhD
 2025-04-29 PHASE1
NCT06778265 ACTIVE_NOT_RECRUITING
Parkinson Disease, Idiopathic
Shanghai UniXell Biotechnology Co., Ltd
 2025-03-01 PHASE1
NCT07289477 RECRUITING
Multiple System Atrophy - Parkinsonian Subtype (MSA-P)
iRegene Therapeutics Co., Ltd.
 2026-01-05 PHASE1
NCT07626034 NOT_YET_RECRUITING
Schizophrenia Disorder
Shanghai Zhongze Therapeutics Co., Ltd.
 2026-08 PHASE1; PHASE2
NCT07106021 ACTIVE_NOT_RECRUITING
Idiopathic Parkinson´s Disease; Parkinson's Disease
Kenai Therapeutics
 2025-07-17 PHASE1; PHASE2
NCT06930261 RECRUITING
Coma, Traumatic
Institut National de la Santé Et de la Recherche Médicale, France
 2025-01-14 PHASE2
NCT07102342 RECRUITING
Parkinson Disease
iRegene Therapeutics Co., Ltd.
 2026-01-12 PHASE1; PHASE2
NCT05117983 ACTIVE_NOT_RECRUITING
Depression
National Cheng-Kung University Hospital
 2021-08-26
NCT06498349 RECRUITING
Parkinson Disease; Impulse Control Disorders
University of Kiel
 2024-09-05
NCT07322133 RECRUITING
Hypotension and Shock; Pulmonary Hypertension of the Newborn (PPHN); Hypoxemic Respiratory Failure
University of California, Davis
 2026-10-30 PHASE4
NCT07215884 RECRUITING
Stuttering, Adult
University of California, San Francisco
 2025-09-30 PHASE1
NCT07804615 NOT_YET_RECRUITING
PARKINSON DISEASE (Disorder)
Vima Therapeutics
 2026-09 PHASE2
NCT06583005 NOT_YET_RECRUITING
Parkinson Disease, Idiopathic
Stanford University
 2025-02-15
NCT05060549 WITHDRAWN
Bipolar Depression
New York State Psychiatric Institute
 2026-01-06 PHASE4
NCT06237868 RECRUITING
Impulse Control Disorder; Parkinson Disease
West Virginia University
 2024-05-01
NCT07423546 RECRUITING
SCHIZOPHRENIA 1 (Disorder); Schizoaffecitve Disorder
New York State Psychiatric Institute
 2026-07-01 PHASE1; PHASE2
NCT03998852 RECRUITING
Apathy
University Hospital, Bordeaux
 2021-04-13 PHASE3
NCT06884722 RECRUITING
Social Perception in Parkinson's Disease
Hospices Civils de Lyon
 2025-07-15
NCT06944522 RECRUITING
Parkinsons Disease (PD)
BlueRock Therapeutics
 2025-06-17 PHASE3
NCT06586320 ENROLLING_BY_INVITATION
Parkinson Disease
Stardots AB
 2025-02-06
NCT06295952 RECRUITING
Prolactin-Producing Pituitary Tumor
Memorial Sloan Kettering Cancer Center
 2024-02-27 PHASE2
NCT05711082 RECRUITING
Neurosciences
Hôpital le Vinatier
 2024-01-15
NCT05635409 ACTIVE_NOT_RECRUITING
Parkinson Disease
Region Skane
 2022-11-30 PHASE1
NCT07397247 NOT_YET_RECRUITING
Restless Legs Syndrome
Noctrix Health, Inc.
 2026-04
NCT06075771 RECRUITING
Anhedonia; Depression
Emory University
 2023-11-21 PHASE4
NCT05765110 RECRUITING
Parkinson Disease
Insel Gruppe AG, University Hospital Bern
 2023-01-03
NCT06763172 RECRUITING
Healthy; Caffeine; Adenosine; Dopamine D2/3 Receptor Availability
Hsiao-Ying Wey
 2023-05-17 PHASE4
NCT02288962 ACTIVE_NOT_RECRUITING
Pituitary Neoplasms; Adenoma
St. Olavs Hospital
 2014-11 PHASE3
NCT06422208 ENROLLING_BY_INVITATION
Parkinson Disease
Penelope J. Hallett, Ph.D.
 2024-08-07 PHASE1
NCT07028632 NOT_YET_RECRUITING
Parkinson Disease (PD)
iRegene Therapeutics Co., Ltd.
 2025-06-30 PHASE2
NCT03778944 RECRUITING
Renal Failure Chronic; Transplant;Failure,Kidney; Anesthesia
Nazmy Edward Seif
 2018-12-20
NCT06675851 RECRUITING
Major Depressive Disorder (MDD)
Medical University of Vienna
 2022-12-01 PHASE4
NCT07775001 ACTIVE_NOT_RECRUITING
Septic Shock
Nishtar Medical University
 2026-02-18
NCT05929898 RECRUITING
Motivation; Memory; Self-regulation
Duke University
 2023-07-30
NCT07617012 NOT_YET_RECRUITING
the Treatment of Multiple System Atrophy Parkinsonian Variant (MSA-P)
XellSmart Bio-Pharmaceutical (Suzhou) Co., Ltd.
 2026-06-15 PHASE1
NCT06978920 RECRUITING
Parkinson Disease
Nuwacell Biotechnologies Co., Ltd.
 2025-06-06 PHASE1
NCT05909267 RECRUITING
Depressive Disorder, Major
Charite University, Berlin, Germany
 2023-07-26
NCT06447740 RECRUITING
Renal Artery Stenosis Atherosclerotic; Secondary Hypertension Renal Arterial
Peking University First Hospital
 2024-06-03
NCT07080775 RECRUITING
Parkinson's Disease
XellSmart Bio-Pharmaceutical (Suzhou) Co., Ltd.
 2025-08-05 PHASE1
NCT04469959 COMPLETED
Late Life Depression; Cognitive Decline; Depressive Disorder, Treatment-Resistant; Levodopa; Gait Impairment
Vanderbilt University Medical Center
 2021-02-15 PHASE2
NCT06608355 RECRUITING
Early-onset Parkinson's Disease
iRegene Therapeutics Co., Ltd.
 2024-08-23 PHASE1
NCT06269146 UNKNOWN
Anxiety Disorders; Anxiety; Depression; Social Disconnection
University of California, San Diego
 2024-05-13 PHASE2
NCT07404813 ENROLLING_BY_INVITATION
Patient Engagement; Intensive Care (ICU); Family Members' Voices
Zeliha CENGİZ
 2025-02-20
NCT03353025 UNKNOWN
Prolactinoma
First Affiliated Hospital, Sun Yat-Sen University
 2016-01-01
NCT05325502 ACTIVE_NOT_RECRUITING
Caffeine
Yu-Shiuan Lin
 2022-05-05
NCT07273526 RECRUITING
Fluid Refractory Septic Shock; Septic Shock
Laiba Qamar
 2025-06-01
NCT06821529 NOT_YET_RECRUITING
Parkinson Disease
iCamuno Biotherapeutics Ltd.
 2025-05-15 PHASE1
NCT06145711 RECRUITING
Parkinson's Disease
Shanghai East Hospital
 2023-11-23
NCT05887466 COMPLETED
Parkinson's Disease
S.Biomedics Co., Ltd.
 2023-05-09 PHASE1; PHASE2
NCT06365515 UNKNOWN
Hormonal Changes; Menstrual Cycle
University Hospital Tuebingen
 2024-05
NCT06167681 RECRUITING
Parkinson Disease
iRegene Therapeutics Co., Ltd.
 2024-01-17 PHASE1; PHASE2
NCT05182892 RECRUITING
Parkinson Disease
Insel Gruppe AG, University Hospital Bern
 2021-12-13
NCT07214285 COMPLETED
Parkinson Disease
University Hospital, Lille
 2025-10-01 PHASE1; PHASE2
NCT03190954 COMPLETED
Normal Physiology; Opioid Use Disorders
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
 2017-08-17 EARLY_PHASE1
NCT05241041 COMPLETED
Gambling
Inha University Hospital
 2021-09-13
NCT06611423 TERMINATED
Heart Failure With Reduced Ejection Fraction (HFrEF); Renal Impairment
AstraZeneca
 2024-10-15 PHASE1
NCT04750070 RECRUITING
Shock Hypovolemic; Shock, Septic; Blood Transfusion; Adrenaline; Dopamine
International Centre for Diarrhoeal Disease Research, Bangladesh
 2021-08-17 PHASE3
NCT04789915 RECRUITING
Psychosis; Negative Symptoms With Primary Psychotic Disorder
Bjorn H. Ebdrup
 2021-05-26 PHASE1
NCT06702124 RECRUITING
Alzheimer Disease
I.R.C.C.S. Fondazione Santa Lucia
 2023-12-01 PHASE3
NCT02965963 COMPLETED
Health
University of Alberta
 2016-12
NCT06300580 COMPLETED
Healthy Volunteers
AbbVie
 2024-08-21 PHASE1
NCT06587217 COMPLETED
Parkinsonian Signs in Older Persons
University of Michigan
 2024-10-29 PHASE1; PHASE2
NCT05732077 UNKNOWN
Renal Artery Stenosis Atherosclerotic; Secondary Hypertension Renal Arterial
Peking University First Hospital
 2023-01-31
NCT06261905 COMPLETED
Opioid Use Disorder
Yale University
 2024-03-13 PHASE1
NCT05022147 ACTIVE_NOT_RECRUITING
Parkinson Disease; Gait Disorders, Neurologic; Disease Progression; Subthalamic Nucleus; Accidental Fall; Deep Brain Stimulation
James Liao
 2021-10-04 PHASE1
NCT06115538 UNKNOWN
Parkinson Disease; Treatment Adherence
Ankara Ataturk Sanatorium Training and Research Hospital
 2023-10-01 PHASE4
NCT05825677 COMPLETED
Stress Response
Hôpital le Vinatier
 2023-04-11
NCT03525002 COMPLETED
Obesity
University Hospital Tuebingen
 2018-05-03 PHASE2
NCT05318924 COMPLETED
Major Depressive Disorder
University Hospital Tuebingen
 2022-02-21 PHASE1; PHASE2
NCT04265209 COMPLETED
Parkinson Disease; Essential Tremor
GE Healthcare
 2021-12-01 PHASE3
NCT05448430 UNKNOWN
Schizophrenia
Central South University
 2022-07-15
NCT05636852 TERMINATED
Parkinson Disease; Movement Disorders
GE Healthcare
 2023-04-24 PHASE2
NCT06219915 COMPLETED
Parkinsonian Signs in Older Persons
University of Michigan
 2024-03-15 PHASE1; PHASE2
NCT04332276 COMPLETED
Parkinson Disease
University Hospital, Lille
 2020-09-18 PHASE1; PHASE2
NCT02233829 WITHDRAWN
Cocaine Abuse
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
 2024-04-23 EARLY_PHASE1
NCT03947216 COMPLETED
Parkinson Disease
University Hospital, Strasbourg, France
 2020-10-23 PHASE2
NCT04107480 UNKNOWN
Prolactinoma; Prolactin-Producing Pituitary Tumor
Leiden University Medical Center
 2019-06-21 PHASE4
NCT05119075 COMPLETED
Parkinson Disease
Insel Gruppe AG, University Hospital Bern
 2021-11-10
NCT04457310 COMPLETED
Early Course Schizophrenia Spectrum Disorder
Yale University
 2021-03-02 PHASE2
NCT06214377 COMPLETED
Parkinson Disease; Pain
Universidad Francisco de Vitoria
 2023-07-01
NCT05369533 COMPLETED
Stroke
University of California, Los Angeles
 2022-08-01 PHASE1; PHASE2
NCT06784570 COMPLETED
Cardiac Surgery; Low Ejection Fraction
Zagazig University
 2021-01-01 PHASE2
NCT05890768 WITHDRAWN
Psychosis
University of New Mexico
 2023-05-11 PHASE4
NCT03146130 TERMINATED
Impulse Control Disorder; Parkinson
Centre Hospitalier Universitaire, Amiens
 2019-01-23 PHASE3
NCT06026917 UNKNOWN
Major Depressive Disorder
Shanghai Mental Health Center
 2023-09-25 PHASE4
NCT04205994 COMPLETED
Decision Making; Executive Function; Dopamine
University of California, Berkeley
 2019-12-01 EARLY_PHASE1
NCT06468371 COMPLETED
Hemodialysis; Restless Legs Syndrome; ESRD (End Stage Renal Disease); Diabetes Complications
Lahore General Hospital
 2022-01-02
NCT04937452 COMPLETED
Frontotemporal Dementia; Dementia; Aphasia, Primary Progressive; Pick Disease of the Brain; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Neurocognitive Disorders; Mental Disorders; Neurodegenerative Diseases; Frontotemporal Lobar Degeneration; TDP-43 Proteinopathies; Proteostasis Deficiencies; Metabolic Disease; Aphasia; Speech Disorders; Language Disorders; Communication Disorders; Neurobehavioral Manifestations; Neurologic Manifestations
I.R.C.C.S. Fondazione Santa Lucia
 2021-06-03 PHASE2
NCT04723147 COMPLETED
Depression; Anhedonia
Emory University
 2021-01-29 PHASE4
NCT05903014 COMPLETED
Nicotine Dependence; Nicotine Addiction
Indonesia University
 2023-01-01 PHASE4
NCT03059563 TERMINATED
Dopamine D2/3 Receptor Availability; Cognitive Function; Methamphetamine Abuse
University of California, Los Angeles
 2018-01-11 PHASE1
NCT05208294 COMPLETED
Placebo Effect on Mood Improvement
Philipps University Marburg
 2021-12-09
NCT04128683 COMPLETED
Anorexia Nervosa
University of California, San Diego
 2020-10-20 EARLY_PHASE1
NCT03709667 COMPLETED
Methamphetamine Abuse
University of California, Los Angeles
 2019-06-26 EARLY_PHASE1
NCT04674670 COMPLETED
Fibromyalgia; Pain, Chronic; Chronic Pain, Widespread
susanne becker
 2021-11-01
NCT05905120 COMPLETED
Major Depressive Disorder
Shanghai Mental Health Center
 2023-03-02 PHASE1
NCT03637075 COMPLETED
Diabetes Mellitus, Type 2
University Hospital Tuebingen
 2017-02-20
NCT04038957 COMPLETED
Schizophrenia
Otsuka Pharmaceutical Development & Commercialization, Inc.
 2019-08-07 PHASE1
NCT04802733 COMPLETED
Advanced Parkinson's Disease
BlueRock Therapeutics
 2021-05-03 PHASE1
NCT06729658 COMPLETED
Healthy Participants
Max Planck Institute for Human Cognitive and Brain Sciences
 2017-10-01 EARLY_PHASE1
NCT03665493 COMPLETED
Idiopathic Parkinson's Disease
Giovanni Mirabella
 2020-09-30
NCT03103750 COMPLETED
ADHD
Yale University
 2017-08-15 PHASE1
NCT04262024 COMPLETED
Health Education
Woman's Health University Hospital, Egypt
 2020-02-01 PHASE1
NCT03216434 UNKNOWN
Post-traumatic Stress Disorder
St. Joseph's Hospital and Medical Center, Phoenix
 2020-01
NCT04451564 UNKNOWN
Fibromyalgia
University of Fribourg
 2021-03
NCT04525495 UNKNOWN
Neonates and Preterm Infants
Seoul National University Hospital
 2020-04-01 PHASE2
NCT04647500 COMPLETED
22q11.2 Deletion Syndrome
University of Geneva, Switzerland
 2016-08-26
NCT05884671 COMPLETED
Sulpiride's Effect on Striatal BOLD Signal During Working Memory Gating; Interaction of Sulpiride, Average Reward Rate and Evidence Accumulation; Interaction of Sulpiride, Average Reward Rate and Cognitive Effort
Donders Centre for Cognitive Neuroimaging
 2021-09-23
NCT04325503 COMPLETED
Parkinsonian Signs in Older Persons
University of Michigan
 2021-02-08 PHASE1; PHASE2
NCT05116813 TERMINATED
Parkinson Disease; Dyskinesia, Drug-Induced; Dyskinesias
Addex Pharma S.A.
 2021-10-25 PHASE2; PHASE3
NCT03693872 COMPLETED
Parkinson Disease
Rennes University Hospital
 2019-05-15
NCT04249544 COMPLETED
Parkinson Disease
Vanderbilt University Medical Center
 2019-12-03 PHASE1
NCT03581305 COMPLETED
Depression; HIV Infections; HIV-Associated Cognitive Motor Complex
National Institutes of Health Clinical Center (CC)
 2018-11-20 PHASE1
NCT01860794 UNKNOWN
Idiopathic Parkinson Disease; Primary Parkinsonism
Bundang CHA Hospital
 2013-05 PHASE1; PHASE2
NCT03648892 COMPLETED
Obesity; Healthy Volunteers; Overweight
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
 2018-09-21 EARLY_PHASE1
NCT04873648 UNKNOWN
Eating Disorders; Intermittent Fasting; Obesity
University of Jordan
 2021-06-20
NCT04968613 UNKNOWN
Parkinson Disease; Memory Impairment
Peking University Third Hospital
 2018-01-01 PHASE4
NCT03515668 UNKNOWN
Muscle Force; Hyperthermia
Brock University
 2018-04-20
NCT03717454 UNKNOWN
Prolactinoma
Zhebao Wu
 2018-12-01
NCT03466697 COMPLETED
Obesity
Pusan National University Hospital
 2018-03-14
NCT04193527 COMPLETED
Parkinsonian Syndrome; Parkinson Disease(PD); Multiple System Atrophy (MSA); Progressive Supranuclear Palsy (PSP); Essential Tremor
GE Healthcare
 2020-06-28 PHASE3
NCT03326245 COMPLETED
Normal Physiology
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
 2018-01-29 PHASE1
NCT06275633 COMPLETED
Parkinson Disease; Medication; UPDRS; Motor Function; Cognitive Impairment; Depression; Impulsive; Levodopa
University Hospital Bispebjerg and Frederiksberg
 2019-03-19
NCT03714763 UNKNOWN
Pituitary Adenoma
Zhebao Wu
 2018-11-01
NCT04493320 TERMINATED
Depression; Cognitive Impairment; Gait Impairment
New York State Psychiatric Institute
 2021-02-10 PHASE4
NCT04588129 COMPLETED
Schizophrenia
LB Pharmaceuticals Inc.
 2021-01-05 PHASE1
NCT03761030 TERMINATED
Major Depressive Disorder; Dysthymia; Depression
New York State Psychiatric Institute
 2019-01-09 PHASE4
NCT04536194 COMPLETED
Anesthesia; Infant; Congenital Heart Disease; Hemodynamic Instability
Children's Hospital of Fudan University
 2020-10-10 PHASE3
NCT02869945 COMPLETED
Parkinson Disease
Assistance Publique - Hôpitaux de Paris
 2016-09
NCT03544229 COMPLETED
Diabetic Gastroparesis; Idiopathic Gastroparesis
Millennium Pharmaceuticals, Inc.
 2018-10-14 PHASE2
NCT04639960 TERMINATED
22q11.2 Deletion Syndrome
University of Geneva, Switzerland
 2017-09-29
NCT03892447 UNKNOWN
Children AKI Patients
Shengjing Hospital
 2019-08-01 PHASE4
NCT02949934 COMPLETED
Alcohol Use Disorder
Medical University of South Carolina
 2016-05-01 PHASE2
NCT04753008 UNKNOWN
Dopamine; Bronchodilation; Heart; Surgery; Functional Disturbance
Szeged University
 2010-12-13
NCT04369430 COMPLETED
Parkinson Disease
Alkahest, Inc.
 2020-01-16 PHASE2
NCT00825045 UNKNOWN
Schizophrenia; Schizoaffective Disorder; Schizophreniform Disorder
Centre for Addiction and Mental Health
 2008-12
NCT01563107 COMPLETED
Postural Orthostatic Tachycardia Syndrome
Vanderbilt University Medical Center
 2012-03
NCT03038308 COMPLETED
Hyperprolactinemia; Prolactinoma
Columbia University
 2016-09-16 PHASE1; PHASE2
NCT03037060 COMPLETED
Alcohol Use Disorder
Centre for Addiction and Mental Health
 2016-12
NCT03863691 COMPLETED
Healthy Participants
Philipps University Marburg
 2019-04-15
NCT03775538 COMPLETED
Parkinson Disease; Movement Disorders; Neuro-Degenerative Disease; Nervous System Diseases; Brain Diseases
Herantis Pharma Plc.
 2018-07-05 PHASE1; PHASE2
NCT00685919 COMPLETED
Postural Tachycardia Syndrome; Orthostatic Intolerance
Vanderbilt University
 2008-05 PHASE2; PHASE3
NCT03104725 TERMINATED
Parkinson Disease; Cerebrospinal Fluid
National Institute of Neurological Disorders and Stroke (NINDS)
 2017-09-25 PHASE1
NCT02513485 COMPLETED
Depression
Emory University
 2015-10-09 PHASE4
NCT04371146 COMPLETED
Healthy
University of Zurich
 2019-07-03
NCT03471806 UNKNOWN
Bulimia Nervosa; Food Reward
Universitaire Ziekenhuizen KU Leuven
 2018-02-16
NCT02637076 COMPLETED
Narcolepsy With Cataplexy; Healthy Controls
Centre for Addiction and Mental Health
 2016-01 PHASE4
NCT04826133 TERMINATED
Cocaine Use Disorder
Yale University
 2019-03-27 EARLY_PHASE1
NCT03295786 COMPLETED
Parkinson Disease; Movement Disorders; Neurodegenerative Diseases; Nervous System Diseases; Brain Diseases
Herantis Pharma Plc.
 2017-09-26 PHASE1; PHASE2
NCT03681509 COMPLETED
Emotions; Motivation; Reward; Dopamine
University of Oxford
 2018-09-01
NCT03205956 COMPLETED
Parkinson's Disease
Kevin J. Black, MD
 2017-10-19 PHASE1
NCT03170739 UNKNOWN
Renal Function
Tao Zhang
 2017-06-06 PHASE4
NCT03349606 COMPLETED
Cocaine Dependence
University of Pittsburgh
 2010-06-02 EARLY_PHASE1
NCT06880328 COMPLETED
Schizophrenia
Hoffmann-La Roche
 2018-11-07 PHASE1
NCT03305705 UNKNOWN
Fatigue; Iron-deficiency
Albina Nowak, MD
 2017-10-23 PHASE4
NCT02706977 COMPLETED
Diabetes
Emory University
 2016-01 PHASE1
NCT03447561 UNKNOWN
Healthy; Food Reward
Universitaire Ziekenhuizen KU Leuven
 2018-02-08
NCT02642315 COMPLETED
Restless Legs Syndrome
University of Missouri-Columbia
 2016-01
NCT03891095 COMPLETED
Oxytocin Group; L-DOPA Group; Placebo Group
Beijing Normal University
 2018-12-01
NCT03107858 UNKNOWN
Renal Transplant
Assiut University
 2017-11-01 PHASE2; PHASE3
NCT02118610 COMPLETED
Schizophrenia
University of Maryland, Baltimore
 2014-09
NCT02428062 SUSPENDED
Post-operative Cognitive Dysfunction
Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
 2014-10 PHASE2; PHASE3
NCT03780686 COMPLETED
Renal Function Test, Urine Output, Lactate Level
Ain Shams University
 2017-04-09
NCT03250741 COMPLETED
Alzheimer Disease
I.R.C.C.S. Fondazione Santa Lucia
 2016-06 PHASE2
NCT03185182 TERMINATED
Clear Cell Renal Cell Carcinoma
Region Skane
 2017-07-14 PHASE2
NCT02542410 COMPLETED
Endometriosis
Boston Children's Hospital
 2016-05 PHASE2
NCT03019822 COMPLETED
Healthy
University Hospital, Basel, Switzerland
 2017-02-01 EARLY_PHASE1
NCT02148783 TERMINATED
Traumatic Brain Injury
Uniformed Services University of the Health Sciences
 2014-09 PHASE2
NCT03512171 COMPLETED
Healthy Adults
Vanderbilt University
 2016-03-31 PHASE1
NCT02560389 COMPLETED
Stress Disorder, Post Traumatic
University of Wisconsin, Madison
 2016-03 PHASE4
NCT02262923 WITHDRAWN
in Vitro Fertilization; Poor Responder
Mount Sinai Hospital, Canada
 2016-03
NCT02929485 WITHDRAWN
Addiction
University of California, Berkeley
 2013-07 PHASE4
NCT03068884 COMPLETED
Cognitive Change
Sheffield Hallam University
 2017-03-01
NCT02726620 COMPLETED
Hypotension
Vanderbilt University Medical Center
 2017-01-05
NCT03854942 TERMINATED
Alcohol Addiction
RWTH Aachen University
 2011-08-30 PHASE1
NCT02587533 COMPLETED
Hypertension, Resistant to Conventional Therapy
Hannover Medical School
 2015-11
NCT03183310 UNKNOWN
Esophageal Reflux
Universitaire Ziekenhuizen KU Leuven
 2017-07-01
NCT02786667 UNKNOWN
Parkinson Disease; Apathy
University Hospital, Grenoble
 2012-06 PHASE3
NCT02989792 COMPLETED
Peripheral Neuropathy; Osteoarthritis
Tools4Patient
 2017-02-08
NCT01482559 TERMINATED
Hypotension; Low Blood Pressure; Intraventricular Hemorrhage of Prematurity
University College Cork
 2015-02 PHASE3
NCT01657760 COMPLETED
Alcohol Dependence
VA Office of Research and Development
 2014-05-01 PHASE1
NCT03476668 COMPLETED
Parkinson Disease; Attention Disturbances
Ospedale Generale Di Zona Moriggia-Pelascini
 2017-01-01
NCT02225106 COMPLETED
Cognition Disorder; Attention Deficit Disorder; Traumatic Brain Injury
University of Pennsylvania
 2014-08-06 PHASE2
NCT01901809 COMPLETED
Heart Failure, Diastolic
Johns Hopkins University
 2013-08 PHASE4
NCT02959892 COMPLETED
Healthy Volunteers
Neurocrine Biosciences
 2016-12-05 PHASE1
NCT02593812 COMPLETED
Parkinson Disease
University of Utah
 2016-07
NCT01878006 COMPLETED
Polymorphism-Genetic; Pain; Addiction
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
 2013-06-13 PHASE2
NCT03271918 COMPLETED
Pituitary Adenoma; Nonfunctioning Pituitary Adenoma
University of Sao Paulo General Hospital
 2015-02-01 PHASE3
NCT02600858 COMPLETED
Parkinson Disease
University of Utah
 2016-01
NCT02015949 COMPLETED
Traumatic Brain Injury
Imperial College London
 2014-02 PHASE4
NCT02033369 COMPLETED
Major Depressive Disorder
New York State Psychiatric Institute
 2014-02 PHASE4
NCT02393027 TERMINATED
Idiopathic Parkinson Disease
University Hospital, Tours
 2015-03 EARLY_PHASE1
NCT02123979 UNKNOWN
Post-op Pain
East Carolina University
 2015-11 PHASE2
NCT02402101 COMPLETED
Transcranial Direct Current Stimulation; Dopamine
Hôpital le Vinatier
 2015-02 PHASE3
NCT02347059 UNKNOWN
Parkinson's Disease
University of Toronto
 2015-01 PHASE2
NCT01999530 COMPLETED
Healthy
Centre for Addiction and Mental Health
 2013-11 PHASE1
NCT00604591 COMPLETED
Frontotemporal Lobar Degeneration
Columbia University
 2008-01-30 PHASE2
NCT01253421 COMPLETED
Major Depressive Disorder (MDD)
Mclean Hospital
 2012-02 PHASE1
NCT01733199 COMPLETED
Parkinson's Disease; Secondary Behavioural Addiction
Nantes University Hospital
 2012-10 PHASE4
NCT03151460 COMPLETED
Parkinson's Disease
I.R.C.C.S. Fondazione Santa Lucia
 2014-09 PHASE4
NCT02134002 WITHDRAWN
Cocaine Dependence
Assistance Publique - Hôpitaux de Paris
 2014-06 PHASE4
NCT01550484 COMPLETED
Parkinson's Disease; Primary Parkinsonism; Lewy Body Parkinson's Disease
Avid Radiopharmaceuticals
 2012-04 PHASE2; PHASE3
NCT02333487 COMPLETED
Schizophrenia
H. Lundbeck A/S
 2014-12-30 PHASE1
NCT02053935 COMPLETED
Hyperglycemia; Sepsis
Albert Einstein College of Medicine
 2013-12 PHASE1
NCT01937169 UNKNOWN
Restless Legs Syndrome
Tel-Aviv Sourasky Medical Center
 2014-01
NCT01292057 COMPLETED
Alcohol Dependence
Medical University of South Carolina
 2011-02 PHASE3
NCT02212405 COMPLETED
Healthy
Centre for Addiction and Mental Health
 2014-07
NCT01780467 UNKNOWN
Parkinson's Disease
University Hospital, Clermont-Ferrand
 2013-03 PHASE4
NCT02387346 UNKNOWN
Parkinson's Disease
Sun Life Financial Movement Disorders Research and Rehabilitation Centre
 2015-04
NCT02038608 COMPLETED
Parkinson's Disease
Hospices Civils de Lyon
 2014-12
NCT01094756 COMPLETED
Obesity
Washington University School of Medicine
 2010-07
NCT01638364 COMPLETED
Heavy Drinking
Centre for Addiction and Mental Health
 2013-01 PHASE1
NCT02203786 COMPLETED
Pathological Gambling
Centre for Addiction and Mental Health
 2009-09 PHASE2
NCT01976871 COMPLETED
Restless Legs Syndrome; Ekbom Syndrome; Willis-Ekbom Disease
John Winkelman, MD, PhD
 2014-08 PHASE4
NCT02438215 COMPLETED
Parkinson's Disease
Io Therapeutics
 2014-08 PHASE1
NCT01788696 COMPLETED
Parkinson Disease
Duke University
 2012-06 PHASE1
NCT01497652 COMPLETED
Parkinson's Disease
Georgetown University
 2012-01 PHASE4
NCT01427686 UNKNOWN
Arterial Hypotension
University of Ulm
 2011-06 PHASE4
NCT02116790 WITHDRAWN
Acute Pain
Northwestern University
 2014-05 PHASE2
NCT01683253 COMPLETED
Impulse Control Disorder
Sandoz
 2012-11 PHASE4
NCT02969629 COMPLETED
Chronic Low Back Pain
Rambam Health Care Campus
 2012-12 PHASE4
NCT01160263 COMPLETED
Amyotrophic Lateral Sclerosis
Assistance Publique - Hôpitaux de Paris
 2012-10 PHASE3
NCT00404170 COMPLETED
Parkinson Disease
Institute for Neurodegenerative Disorders
 2006-11 PHASE2
NCT02189564 COMPLETED
Motor Performance; Motor Learning
Kai Lutz, PhD
 2014-01
NCT02152670 TERMINATED
Cocaine Dependence
Yale University
 2014-05
NCT02009007 UNKNOWN
Hypoxia; Hypotension
Samsung Medical Center
 2012-12 PHASE1
NCT02201121 COMPLETED
Circulation; Drug Dose; Calculated SAP
Chinese PLA General Hospital
 2014-03
NCT02093169 COMPLETED
Healthy Men
H. Lundbeck A/S
 2014-02 PHASE1
NCT01699828 COMPLETED
Smoking Cessation; Tobacco Use Cessation
Centre for Addiction and Mental Health
 2012-10 PHASE1; PHASE2
NCT02241083 COMPLETED
Head and Neck Cancer
Tampere University Hospital
 2006-06 PHASE4
NCT02557984 COMPLETED
Addiction
University of Zurich
 2014-02
NCT02428933 COMPLETED
Obesity
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
 2013-10
NCT01039090 COMPLETED
Parkinsons's Disease
Rennes University Hospital
 2009-02 PHASE3
NCT01060293 TERMINATED
Acute Decompensated Heart Failure
Larissa University Hospital
 2009-07 PHASE4
NCT00917709 COMPLETED
Dementia With Lewy Bodies
University Hospital, Bordeaux
 2009-05
NCT01132846 COMPLETED
Acute Heart Failure
Duke University
 2010-08 PHASE2
NCT01132326 COMPLETED
Primary Autonomic Failure; Dopamine Beta Hydroxylase Deficiency; Non-Diabetic Neuropathy; Neurogenic Orthostatic Hypotension
Chelsea Therapeutics
 2009-01 PHASE3
NCT02862093 COMPLETED
Alcohol Dependence
Catholic University of the Sacred Heart
 2010-01
NCT01318278 COMPLETED
Hypotension
Baylor College of Medicine
 2011-03
NCT01432821 COMPLETED
Idiopathic Generalized Epilepsy
Institut National de la Santé Et de la Recherche Médicale, France
 2011-09
NCT00701532 COMPLETED
Cocaine Addiction; Cocaine Dependence
Assistance Publique - Hôpitaux de Paris
 2009-04 PHASE3
NCT01049984 COMPLETED
Parkinson's Disease
Teva Neuroscience, Inc.
 2009-12 PHASE4
NCT00659230 COMPLETED
Posttraumatic Stress Disorder
Tuscaloosa Research & Education Advancement Corporation
 2009-07-01 PHASE2
NCT00396669 UNKNOWN
Tobacco Use Disorder
Hadassah Medical Organization
 2007-07
NCT01722630 COMPLETED
Intra Operative Fluid Management
Catholic University of the Sacred Heart
 2012-03
NCT01297738 COMPLETED
Obesity; Diabetes Mellitus Type 2
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
 2011-02
NCT00748228 TERMINATED
Postural Tachycardia Syndrome
Vanderbilt University
 2004-11
NCT00953745 COMPLETED
Major Depressive Disorder
Washington University School of Medicine
 2009-05
NCT01218425 COMPLETED
Dopamine Activity; Episodic Memory Consolidation; Response Preparation
Maastricht University Medical Center
 2010-11
NCT01620138 COMPLETED
Non-functioning Pituitary Adenomas; Prolactinomas
Universidade Federal do Rio de Janeiro
 2010-03 PHASE2; PHASE3
NCT01361373 UNKNOWN
Dystonic Cerebral Palsy
Shaare Zedek Medical Center
 2010-05 PHASE4
NCT01028586 TERMINATED
Idiopathic Parkinson's Disease
Newron Pharmaceuticals SPA
 2009-10 PHASE3
NCT01531972 COMPLETED
Healthy
Sumitomo Pharma America, Inc.
 2012-02 PHASE1
NCT00605683 COMPLETED
Idiopathic Parkinson's Disease
Newron Pharmaceuticals SPA
 2007-11 PHASE3
NCT01264861 TERMINATED
Parkinson Disease
Newron Pharmaceuticals SPA
 2011-03 PHASE2
NCT00627640 COMPLETED
Idiopathic Parkinson's Disease
Newron Pharmaceuticals SPA
 2009-02 PHASE3
NCT00581009 COMPLETED
Major Depressive Disorder; Bipolar Disorder
University of California, Irvine
 2001-05-30 PHASE1; PHASE2
NCT01007864 COMPLETED
Idiopathic Parkinson's Disease
Desitin Arzneimittel GmbH
 2010-01 PHASE3
NCT01313819 UNKNOWN
Parkinson's Disease; Freezing of Gait
Seoul National University Hospital
 2011-04 PHASE4
NCT00931996 TERMINATED
Schizophrenia
University of Illinois at Chicago
 2009-06
NCT01503944 COMPLETED
Dementia With Lewy Bodies; Alzheimer's Disease; Parkinson's Disease
Avid Radiopharmaceuticals
 2010-03 PHASE1; PHASE2
NCT01744964 COMPLETED
Healthy
Rambam Health Care Campus
 2009-07 EARLY_PHASE1
NCT00665184 COMPLETED
Parkinson Disease
University of Utah
 2007-08
NCT01106053 WITHDRAWN
Binge Eating Disorder
Neuropsychiatric Research Institute, Fargo, North Dakota
 2010-04 PHASE3
NCT01065376 COMPLETED
In Vitro Fertilization
Shin Kong Wu Ho-Su Memorial Hospital
 2010-01 PHASE4
NCT01140399 TERMINATED
Acute Decompensated Heart Failure
Niguarda Hospital
 2011-02 PHASE4
NCT01325831 COMPLETED
Major Depression
Yonsei University
 2009-05 PHASE4
NCT01045083 COMPLETED
Healthy Volunteer
Hoffmann-La Roche
 2010-01 PHASE1
NCT00802204 COMPLETED
Obesity
Vanderbilt University
 2008-12
NCT00818298 COMPLETED
Schizophrenia; Schizoaffective Disorder
Centre for Addiction and Mental Health
 2009-01
NCT00874393 COMPLETED
Infant, Newborn; Infant, Low Birth Weight; Infant, Small for Gestational Age; Infant, Premature; Hypotension; Blood Pressure
NICHD Neonatal Research Network
 2009-07 PHASE1
NCT00738062 COMPLETED
Neurogenic Orthostatic Hypotension; Non-Diabetic Autonomic Neuropathy; Multiple System Atrophy; Dopamine Beta Hydroxylase Deficiency
Chelsea Therapeutics
 2008-01 PHASE3
NCT01191645 COMPLETED
Opioid Induced Pharyngeal and Esophageal Dysfunction
Region Örebro County
 2010-10 PHASE4
NCT01140620 COMPLETED
Healthy Volunteers; Schizophrenia
University of Manchester
 2010-06 PHASE4
NCT00634556 COMPLETED
Tourette Syndrome
Washington University School of Medicine
 2006-02 PHASE1
NCT01365364 COMPLETED
Periodic Limb Movements in Sleep
Federal University of São Paulo
 2009-03
NCT00782340 COMPLETED
Symptomatic Neurogenic Orthostatic Hypotension (NOH); Non-diabetic Neuropathy; Primary Autonomic Failure; Dopamine Beta Hydroxylase Deficiency
Chelsea Therapeutics
 2008-09 PHASE3
NCT00206960 COMPLETED
Schizophrenia
Birte Glenthoj
 1998-01
NCT00663338 COMPLETED
Right Hemisphere Stroke; Hemispatial Neglect; Motor Deficit
University College, London
 2010-01 PHASE2
NCT00942253 COMPLETED
Restless Legs Syndrome; End Stage Renal Disease; Hemodialysis; Muscle Cachexia; Sleep Disorders
University of Thessaly
 2006-09 PHASE2
NCT00086307 COMPLETED
Major Depression
National Institute of Mental Health (NIMH)
 2004-06 PHASE2
NCT00940914 COMPLETED
Parkinson's Disease; Pain
University Hospital, Toulouse
 2009-03 PHASE2
NCT00937092 UNKNOWN
Acute Heart Failure
Larissa University Hospital
 2009-01 PHASE4
NCT00228371 TERMINATED
Epilepsy; Drug Resistant
University Hospital, Grenoble
 2005-09 PHASE2; PHASE3
NCT00149630 COMPLETED
Cocaine Dependence; Opioid Dependence
Baylor College of Medicine
 2005-01 PHASE2
NCT00145132 COMPLETED
Depression
Ludwig-Maximilians - University of Munich
 2005-06 PHASE4
NCT01278342 COMPLETED
Acromegaly
Novartis Pharmaceuticals
 2006-09 PHASE4
NCT01153802 COMPLETED
Depressive Disorder
GlaxoSmithKline
 2009-04-03 PHASE1
NCT00633880 COMPLETED
Symptomatic Neurogenic Orthostatic Hypotension (NOH); Non-diabetic Neuropathy; Primary Autonomic Failure; Dopamine Beta Hydroxylase Deficiency
Chelsea Therapeutics
 2008-01 PHASE3
NCT00604019 COMPLETED
Septic Shock
Rush University Medical Center
 2003-03 PHASE3
NCT00941265 COMPLETED
Aphasia
University Hospital, Geneva
 2007-02
NCT00038116 COMPLETED
Parkinson Disease
University of Colorado, Denver
 1995-05 PHASE3
NCT00814957 COMPLETED
Substance Dependence
GlaxoSmithKline
 2008-12-08 PHASE1
NCT00867360 TERMINATED
Affective Disorders, Psychotic; Depressive Disorder
Stanford University
 2005-08 PHASE3
NCT00465452 COMPLETED
Parkinson Disease
University of Toledo
 2007-01 PHASE3
NCT00846339 COMPLETED
Smoking
Seoul National University Hospital
 2008-11 PHASE4
NCT00580814 COMPLETED
Attention Deficit Hyperactivity Disorder
University of California, Irvine
 2006-02
NCT00566462 TERMINATED
Parkinson's Disease
Eisai Inc.
 2007-10 PHASE2
NCT00484133 UNKNOWN
Severe Sepsis; Microcirculation
Onze Lieve Vrouwe Gasthuis
 2007-06 PHASE4
NCT00603018 COMPLETED
Anorexia Nervosa
University of Pittsburgh
 2007-06
NCT00225498 COMPLETED
Schizophrenia
Northwell Health
 2002-06
NCT01187966 COMPLETED
Parkinson's Disease
Newron Pharmaceuticals SPA
 2007-01 PHASE3
NCT00443872 COMPLETED
Parkinson's Disease
Parkinson's Disease and Movement Disorder Center of Boca Raton
 2007-03 PHASE4
NCT00153972 COMPLETED
Parkinson's Disease
Technische Universität Dresden
 2005-02 PHASE4
NCT00370500 COMPLETED
Schizophrenia
University of Erlangen-Nürnberg Medical School
 2007-04 PHASE4
NCT00305331 TERMINATED
Parkinson's Disease; Peripheral Edema
University Health Network, Toronto
 2006-03 PHASE2
NCT00592943 COMPLETED
Healthy
Massachusetts General Hospital
 2007-10 PHASE1; PHASE2
NCT00468806 COMPLETED
Healthy Subjects
GlaxoSmithKline
 2007-04 PHASE1
NCT00592150 UNKNOWN
Hypertension
University of Virginia
 2007-06 PHASE1
NCT00595140 COMPLETED
Acromegaly
Ludwig-Maximilians - University of Munich
 2008-01 PHASE4
NCT01066403 COMPLETED
Schizophrenia
Heidelberg University
 2003-10
NCT00593138 COMPLETED
Drug Binding to DAT Receptors
Massachusetts General Hospital
 2006-12 PHASE1; PHASE2
NCT00115115 COMPLETED
Kidney Transplantation; ESRD
Universitätsmedizin Mannheim
 2004-03 PHASE4
NCT00166322 COMPLETED
Schizophrenia
Ludwig-Maximilians - University of Munich
 2004-01
NCT00471588 COMPLETED
Obsessive-Compulsive Disorder
GlaxoSmithKline
 2006-08 PHASE1
NCT00126087 TERMINATED
Stroke
University Hospital Muenster
 2005-07 PHASE4
NCT00314704 COMPLETED
Shock
Sepsis Occurrence in Acutely Ill Patients
 2003-12 PHASE3
NCT02845037 COMPLETED
Hypertension; Chronic Heart Failure
Bial - Portela C S.A.
 2007-05 PHASE1
NCT00231959 COMPLETED
Depression
Massachusetts General Hospital
 2003-09 PHASE4
NCT00269035 COMPLETED
Schizophrenia
GlaxoSmithKline
 2005-06-21 PHASE1
NCT00666653 COMPLETED
Parkinson's Disease
Oregon Health and Science University
 2003-07 PHASE1
NCT00134784 COMPLETED
Parkinson Disease
Institute for Neurodegenerative Disorders
 2000-04 PHASE2
NCT00472355 WITHDRAWN
Parkinson's Disease
Oregon Health and Science University
 2005-10 PHASE2
NCT00220272 COMPLETED
Parkinson Disease
Sanofi
 2004-01 PHASE2
NCT00102869 COMPLETED
Cerebrovascular Accident; Aphasia
University Hospital Muenster
 2005-01 PHASE4
NCT00302393 COMPLETED
Healthy
Massachusetts General Hospital
 2006-06 PHASE3
NCT00642889 COMPLETED
Parkinson's Disease
Newron Pharmaceuticals SPA
 2005-06 PHASE3
NCT00129181 COMPLETED
Parkinson Disease; Parkinsonian Syndrome
Institute for Neurodegenerative Disorders
 2005-01
NCT00280501 COMPLETED
Regional Blood Flow; Ocular Physiology
Medical University of Vienna
 2005-08
NCT00643045 COMPLETED
Idiopathic Parkinson's Disease
Newron Pharmaceuticals SPA
 2004-12 PHASE3
NCT01324245 COMPLETED
Salt-sensitive Hypertension
Georgetown University
 2002-11
NCT00301639 COMPLETED
Healthy Volunteers
Massachusetts General Hospital
 2005-03 PHASE3
NCT00625014 COMPLETED
Insulin Resistance; Dyslipidemia
Leiden University Medical Center
 2005-03
NCT01044992 COMPLETED
Multisystemic Atrophy
University Hospital, Toulouse
 2002-05
NCT00144209 COMPLETED
Restless Legs Syndrome
Boehringer Ingelheim
 2003-02 PHASE3
NCT00625170 COMPLETED
Insulin Resistance; Dyslipidemia
Leiden University Medical Center
 2004-05
NCT00200447 COMPLETED
Parkinson's Disease
Molecular NeuroImaging
 2004-03 PHASE2
NCT00302367 COMPLETED
Healthy Volunteers
Massachusetts General Hospital
 2004-01 PHASE4
NCT02233023 COMPLETED
Parkinson Disease
Boehringer Ingelheim
 1998-06 PHASE4
NCT00000309 TERMINATED
Cocaine-Related Disorders
Butler Hospital
 1994-08 PHASE2
NCT00000276 TERMINATED
Cocaine-Related Disorders
Yale University
 1994-09 PHASE1
NCT03347955 COMPLETED
Parkinson Disease; Surgery
University of Denver
 1994-11
NCT00000310 TERMINATED
Cocaine-Related Disorders
National Institute on Drug Abuse (NIDA)
 1996-01 PHASE2
NCT00440258 COMPLETED
Ovarian Hyperstimulation Syndrome
Instituto Valenciano de Infertilidad, IVI VALENCIA
 2004-04 PHASE3
NCT00335205 UNKNOWN
Bipolar Disorder; Major Depressive Disorder
Sheba Medical Center
 2003-04 PHASE4
NCT00491062 COMPLETED
Parkinson's Disease
Nantes University Hospital
 2007-06
NCT00083629 COMPLETED
Healthy
National Institute of Mental Health (NIMH)
 2004-05 PHASE1
NCT00088517 COMPLETED
Healthy
National Institute of Mental Health (NIMH)
 2004-07 PHASE1
NCT00254033 COMPLETED
Dementia; Alzheimer Disease
Sunnybrook Health Sciences Centre
 2003-10 PHASE4
NCT00000315 COMPLETED
Cocaine-Related Disorders
National Institute on Drug Abuse (NIDA)
 1996-11 PHASE1
NCT00000316 COMPLETED
Cocaine-Related Disorders
National Institute on Drug Abuse (NIDA)
 1996-08 PHASE1
NCT00306124 UNKNOWN
Alzheimer's Disease; Mild Cognitive Impairment; Healthy
University Hospital Muenster
 2006-01 PHASE4
NCT00252044 UNKNOWN
Schizotypal Personality Disorder; Other Personality Disorders
Bronx VA Medical Center
 2000-10
NCT00000350 UNKNOWN
Amphetamine-Related Disorders; Tobacco Use Disorder
National Institute on Drug Abuse (NIDA)
 1999-03 PHASE1
NCT00001931 COMPLETED
Parkinson Disease
National Institute of Neurological Disorders and Stroke (NINDS)
 1999-05 PHASE2
NCT00025792 COMPLETED
Bipolar Disorder
National Institute of Mental Health (NIMH)
 2001-10 PHASE2
NCT00209508 COMPLETED
Parkinson's Disease
Eisai Inc.
 2002-11 PHASE2
NCT00062946 COMPLETED
Healthy
National Institute of Mental Health (NIMH)
 2003-06-17 PHASE2
NCT00832221 COMPLETED
Depression
AstraZeneca
 2009-01 PHASE1
NCT00111371 UNKNOWN
Dyslexia
University Hospital Muenster
 2005-01 PHASE4

(data from https://clinicaltrials.gov, updated on 2026-07-28)

Check the Dopamine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Dopamine functions as an endogenous agonist that selectively binds G protein-coupled dopamine receptor subtypes, stimulating intracellular cyclic adenosine monophosphate production and modulating downstream signaling cascades to regulate vascular tone and neural communication. This receptor activation mediates dose-dependent hemodynamic and physiological responses, providing targeted therapeutic management for trial-studied conditions such as hypotension and septic shock.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

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Note: Technical data last updated: Sep 1, 2026.