CAS No. 120014-06-4
Batch:
Purity:99.96
Chemical Structure
Check the
Donepezil
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one | |
|---|---|---|
| CAS Number | 120014-06-4 | |
| Molecular Formula |
C24H29NO3 |
|
| Molecular Weight (MW) | 379.49 | |
| SMILES | COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC | |
| InChIKey | ADEBPBSSDYVVLD-UHFFFAOYSA-N |
Donepezil is a piperidine-based, highly potent, specific, reversible, and non-competitive inhibitor of acetylcholinesterase (AChE). By suppressing AChE enzyme activity, it effectively prevents the enzymatic degradation of acetylcholine and enhances cholinergic neurotransmission within the central nervous system. This sustained elevation of acetylcholine levels modulates synaptic transmission, attenuates memory deficits, and improves overall cognitive performance in preclinical models of dementia. [1][2]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
75 mg/mL
(197.63 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.