CAS No. 6217-54-5

Batch: Purity:99.91
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DHA (Docosahexaenoic Acid) Chemical Structure
Chemical Structure
Check the DHA (Docosahexaenoic Acid) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoic acid
CAS Number 6217-54-5
Molecular Formula

C22H32O2
Molecular Weight (MW) 328.49
SMILES CCC=CCC=CCC=CCC=CCC=CCC=CCCC(=O)O
InChIKey MBMBGCFOFBJSGT-KUBAVDMBSA-N

Biological Activity

DHA (Docosahexaenoic Acid) is an essential omega-3 polyunsaturated fatty acid that serves as a major structural constituent of brain cell membranes. It modulates membrane fluidity and signaling cascades, including the AKT/mTOR and NF-kB pathways, to support neuronal survival and synaptic plasticity. Consequently, DHA plays a vital role in infant brain development and the maintenance of cognitive function in adults. [1][2]

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 66 mg/mL (200.91 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Lauritzen L, et al. Nutrients. 2016;8(1).

[2] Horrocks LA, et al. Pharmacol Res. 1999;40(3):211-25.

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Note: Technical data last updated: Sep 1, 2026.