CAS No. 2379-57-9
Batch:
Purity:97
Chemical Structure
Check the
DNQX
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 2379-57-9 | |
|---|---|---|
| Molecular Formula |
C8H4N4O6 |
|
| Molecular Weight (MW) | 252.14 | |
| SMILES | O=C1NC2=CC(=C(C=C2NC1=O)[N;v5](=O)=O)[N;v5](=O)=O |
DNQX is a competitive AMPA receptor antagonist that selectively targets non-NMDA ionotropic glutamate receptors. By blocking receptor activation, it prevents neuronal membrane depolarization and prevents excess calcium influx via voltage-gated calcium channels. This downstream channel block attenuates fast excitatory postsynaptic currents, dampens glutamatergic signaling pathways, and protects central neurons against excitotoxicity-mediated cell death and tissue injury.
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
50 mg/mL
(198.3 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.