CAS No. 35973-25-2
Batch:
Purity:98.01
Chemical Structure
Check the
DNA2 inhibitor C5
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 35973-25-2 | |
|---|---|---|
| Molecular Formula |
C10H6N2O5 |
|
| Molecular Weight (MW) | 234.17 |
Biological Activity
DNA2 inhibitor C5 (NSC-15765) is a potent, competitive, and specific DNA2 nuclease inhibitor. By targeting an allosteric pocket near the DNA-binding site, it comprehensively shuts down the multi-catalytic functions of DNA2, suppressing its nuclease, DNA-dependent ATPase, helicase, and direct DNA-binding activities. This inhibition disrupts double-strand break repair and homologous recombination pathways, leading to compromised genome stability.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
47 mg/mL
(200.7 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Note: Technical data last updated: Sep 1, 2026.