CAS No. 1031063-36-1
Batch:
Purity:99.88
Chemical Structure
Check the
DMU2105
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | (E)-3-naphthalen-2-yl-1-pyridin-3-ylprop-2-en-1-one | |
|---|---|---|
| CAS Number | 1031063-36-1 | |
| Molecular Formula |
C18H13NO |
|
| Molecular Weight (MW) | 259.30 | |
| SMILES | C1=CC=C2C=C(C=CC2=C1)C=CC(=O)C3=CN=CC=C3 | |
| InChIKey | VWBDGXJRQZDLRV-CSKARUKUSA-N |
Biological Activity
DMU2105 is a potent and selective cytochrome P450 1B1 (CYP1B1) inhibitor. By targeted inhibition of CYP1B1 enzymatic activity, DMU2105 blocks the metabolic activation of various pro-carcinogens and xenobiotics. This pathway intervention prevents the generation of reactive metabolites, dampens downstream pro-oncogenic signaling cascades, and effectively suppresses cancer cell proliferation and survival in CYP1B1-overexpressing tumor models.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
25 mg/mL
(96.41 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 2 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Jump to
Note: Technical data last updated: Sep 1, 2026.