CAS No. 1206711-16-1
Batch:
Purity:99.92
Chemical Structure
Check the
DMH1
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-[6-(4-propan-2-yloxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | |
|---|---|---|
| CAS Number | 1206711-16-1 | |
| Molecular Formula |
C24 H20 N4 O |
|
| Molecular Weight (MW) | 380.44 | |
| SMILES | CC(C)OC1=CC=C(C=C1)C2=CN3C(=C(C=N3)C4=CC=NC5=CC=CC=C45)N=C2 | |
| InChIKey | JMIFGARJSWXZSH-UHFFFAOYSA-N |
DMH1 is a selective bone morphogenetic protein (BMP) receptor inhibitor that targets ALK2 with an IC50 of, showing no significant inhibition against AMPK, ALK5, KDR, or PDGFR. By selectively blocking ALK2 activity, DMH1 disrupts downstream BMP/Smad signaling pathways, leading to the suppression of target gene transcription and the inhibition of cellular autophagy. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
25 mg/mL
(65.71 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
32 mg/mL
(84.11 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
15 mg/mL
(39.42 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
12 mg/mL
(31.54 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
15 mg/mL
(39.42 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- DMH1 Mechanism of Action: ALK2 Inhibition in Cancer Cell Research
- DMH1 Working Concentration | Cell Culture | Treatment
- DMH1 Solubility in DMSO
- DMH1 Stock Solution
- DMH1 Storage
- DMH1 Stability
- DMH1 Combination Database
- DMH1 Molecular Weight
- DMH1 SMILES
- DMH1 Chemical Structure (2D and 3D)
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Note: Technical data last updated: Sep 1, 2026.