CAS No. 796073-69-3
Batch:
Purity:99.93
Chemical Structure
Check the
DM4
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | [(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl] (2S)-2-[methyl-(4-methyl-4-sulfanylpentanoyl)amino]propanoate | |
|---|---|---|
| CAS Number | 796073-69-3 | |
| Molecular Formula |
C38H54ClN3O10S |
|
| Molecular Weight (MW) | 780.37 | |
| InChIKey | JFCFGYGEYRIEBE-YVLHJLIDSA-N |
DM4 is a targeted maytansinoid derivative that acts as a potent inhibitor of tubulin. By binding to α/β-tubulin heterodimers, it suppresses microtubule dynamic instability and inhibits tubulin polymerization. This disruption of microtubule assembly impairs mitotic spindle formation, resulting in cell cycle arrest at the G2/M phase and triggering apoptotic cell death in various cancer models, including acute myeloid leukemia. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Ethanol | 50 mg/mL |
| DMSO |
20 mg/mL
(25.62 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.