CAS No. 1190197-97-7

Batch: Purity:
DLin-KC2-DMA Chemical Structure
Chemical Structure
Check the DLin-KC2-DMA product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 1190197-97-7
Molecular Formula

C43H79NO2
Molecular Weight (MW) 642.09
SMILES CCCCCC=CCC=CCCCCCCCCC1(OCC(O1)CCN(C)C)CCCCCCCCC=CCC=CCCCCC

Biological Activity

DLin-KC2-DMA is an ionizable cationic lipid widely utilized in lipid nanoparticle formulations for nucleic acid delivery. It facilitates efficient cellular uptake and endosomal escape of small interfering RNAs, enabling potent targeted gene silencing in vivo, particularly against hepatic mRNA targets. This lipid-mediated delivery system significantly enhances systemic RNA interference therapeutics without eliciting pronounced immunostimulatory responses. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Semple SC, et al. Nat Biotechnol. 2010;28(2):172-6.

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Note: Technical data last updated: Sep 1, 2026.