CAS No. 76721-89-6
Batch:
Purity:99.00
Chemical Structure
Check the
DL-Thiorphan
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 2-[(2-benzyl-3-sulfanylpropanoyl)amino]acetic acid | |
|---|---|---|
| CAS Number | 76721-89-6 | |
| Molecular Formula |
C12H15NO3S |
|
| Molecular Weight (MW) | 253.32 | |
| InChIKey | LJJKNPQAGWVLDQ-UHFFFAOYSA-N |
Biological Activity
DL-Thiorphan is a potent inhibitor of neprilysin (also known as enkephalinase) that selectively blocks the enzymatic degradation of endogenous opioid peptides. By inhibiting neprilysin-mediated cleavage, DL-Thiorphan effectively elevates local concentrations of enkephalins within the central nervous system. This enhancement promotes downstream stimulation of mu and delta opioid receptor signaling pathways, which ultimately mediates pronounced antinociceptive and analgesic phenotypes. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
51 mg/mL
(201.32 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 51 mg/mL |
| Water | 4 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.