CAS No. 2253744-53-3
Batch:
Purity:99.95
Chemical Structure
Check the
DJ-V-159
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 2253744-53-3 | |
|---|---|---|
| Molecular Formula |
C24H12F6N4O2 |
|
| Molecular Weight (MW) | 502.37 | |
| SMILES | C1=CC(=CC(=C1)C(=O)NC2=CC(=C(C=C2)C#N)C(F)(F)F)C(=O)NC3=CC(=C(C=C3)C#N)C(F)(F)F |
DJ-V-159 is a small-molecule agonist targeting G protein-coupled receptor family C group 6 member A (GPRC6A). Activation of GPRC6A stimulates intracellular signaling pathways, including extracellular signal-regulated kinase (ERK) phosphorylation and second messenger cascades. Through these signaling events, GPRC6A stimulation modulates endocrine responses, metabolic regulation, and cellular proliferation phenotypes. Consequently, DJ-V-159 serves as a valuable chemical tool for investigating GPRC6A-mediated nutrient sensing and physiological signaling mechanisms. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
6 mg/mL
(11.94 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.