Disodium Phosphate SDS/MSDS (Safety Data Sheet)

3.1 Substances
Product name: Disodium Phosphate
CAS Number: 7558-79-4
PubChem CID: 24203
Molecular formula: HNa2O4P
Molecular weight: 141.959 g/mol
IUPAC name: disodium;hydrogen phosphate

3.2 Mixtures
Not applicable (pure substance).

4.1 Description of first aid measures
Inhalation: Fresh air, rest.
Skin contact: Rinse skin with plenty of water or shower.
Eye contact: First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion: Rinse mouth. Give one or two glasses of water to drink.

4.2 Most important symptoms and effects, both acute and delayed
See Section 11 (Toxicological Information).

4.3 Indication of any immediate medical attention and special treatment needed
Treat symptomatically. Contact a poison control center or physician for severe exposure.

5.1 Extinguishing media
Suitable: Water spray, dry chemical, carbon dioxide (CO2), alcohol-resistant foam.
Unsuitable: None known.

5.2 Specific hazards arising from the substance or mixture
In case of fire in the surroundings, use appropriate extinguishing media.
If material is on fire or involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.)
Behavior in fire: May melt with loss of steam. /Sodium Phosphates/

5.3 Advice for firefighters
Wear self-contained breathing apparatus (SCBA) and full protective clothing.
Fight fire from upwind. Cool containers with water spray until fire is extinguished.

6.1 Personal precautions, protective equipment and emergency procedures
Wear appropriate personal protective equipment (see Section 8).
Avoid breathing dust/vapor. Ensure adequate ventilation.
Evacuate personnel to safe areas. Keep people away from and upwind of spill.

6.2 Environmental precautions
Prevent product from entering drains, waterways, or soil.
Contain spill with inert absorbent material.

6.3 Methods and materials for containment and cleaning up
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting.
/SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./Environmental Consideration: Land spill Dig a pit, pond, lagoon, holding area to contain liquid or solid material. Cover solids with a plastic sheet to prevent dissolving in rain or fire fighting water.
Environmental Consideration: Neutralize with agricultural lime (CaO), crushed limestone (CaCO3), or sodium bicarbonate (NaHCO3). Adjust pH to neutral (pH=7). Use mechanical dredges or lifts to remove immobilized masses of pollutants and precipitates.
SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.
SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.
If material is not on fire and not involved in fire: Keep material out of water sources and sewers. Build dikes to contain flow as necessary.
Personnel Protection: Keep upwind. Wear appropriate chemical protective gloves, boots and goggles. Avoid breathing vapors or dusts. Wash away any material which may have contacted the body with copious amounts of water or soap and water.

7.1 Precautions for safe handling
Separated from strong acids.
Keep well closed and in a cool place.

7.2 Conditions for safe storage, including any incompatibilities
Separated from strong acids.
Keep well closed and in a cool place.
Store away from incompatible materials (see Section 10).
[Note: Specific storage temperature not available in public databases. Refer to supplier Certificate of Analysis (COA) for exact storage conditions.]

9.1 Information on basic physical and chemical properties
a) Appearance: Sodium phosphate, dibasic appears as a colorless to white crystalline solid. Soluble in water. The primary hazard is the threat to the environment. Immediate steps should be taken to limit spread to the environment. Used as a fertilizer, in pharmaceuticals, in food processing, and for many other uses.
b) Odor: No data available
c) Odor threshold: No data available
d) pH: Between 8,4 and 9,6 (1 % solution)
e) Melting point/freezing point: MP: loses H2O at 92.5 °C; Specific gravity: 2.066 at 15 °C /Disodium phosphate dihydrate/
f) Initial boiling point and boiling range: No data available
g) Flash point: No data available
h) Evaporation rate: No data available
i) Flammability (solid, gas): No data available
j) Upper/lower flammability or explosive limits: No data available
k) Vapor pressure: No data available
l) Vapor density: No data available
m) Relative density: 1.8 to 2.5 at 77 °F (USCG, 1999)
n) Water solubility: greater than or equal to 100 mg/mL at 68 °F (NTP, 1992)
o) Partition coefficient: n-octanol/water: Log P: No data available
p) Auto-ignition temperature: No data available
q) Decomposition temperature: No data available
r) Viscosity: No data available
s) Explosive properties: No data available
t) Oxidizing properties: No data available

9.2 Other information
Topological Polar Surface Area (TPSA): 83.4 Ų
Complexity: 46

11.1 Information on toxicological effects
Acute toxicity:
No acute toxicity data available.
Skin corrosion/irritation:
No data available.
Serious eye damage/eye irritation:
Causes serious eye irritation (H319).
Respiratory or skin sensitization:
No data available.
Germ cell mutagenicity:
No data available.
Carcinogenicity:
No data available.
Reproductive toxicity:
No data available.
Specific target organ toxicity (single exposure):
No data available.
Specific target organ toxicity (repeated exposure):
No data available.
Aspiration hazard:
No data available.

11.2 Additional information
Signs and symptoms of exposure:
Cough. Sore throat.
Redness. Pain.
Redness. Pain.
Abdominal pain. Diarrhoea.
Data source: Hazardous Substances Data Bank (HSDB) via PubChem.

12.1 Toxicity
LC50; Species: Daphnia magna (Water flea); Condtions: freshwater, static, 21-25 °C; Concentration: 1154 mg/L for 25 hr
LC50; Species: Daphnia magna (Water flea); Condtions: freshwater, static, 21-25 °C; Concentration: 1089 mg/L for 50 hr
7.80e+04
1.20e+06
2.00e+04
1.5E+01(G)
1.00e+00
Volatile
Mutagen
1
2.30e+05
3.50e+06
6.00e+04
1.5E+01 (G)
1.00e+00
Volatile
Mutagen
1
In August of 1987, 30,000 gallons of sodium phosphate was spilled into the Arthur Krill waterway, NY(1).
NIOSH (NOES Survey 1981-1983) has statistically estimated that 1,230,592 workers (912,048 of these were female) were potentially exposed to disodium hydrogen phosphate in the US(1). The NOES Survey does not include farm workers. Occupational exposure to disodium hydrogen phosphate may occur through inhalation and dermal contact with this compound at workplaces where disodium hydrogen phosphate is produced or used(SRC).

12.2 Persistence and degradability
No data available.

12.3 Bioaccumulative potential
No data available.

12.4 Mobility in soil
No data available.

12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available.

12.6 Other adverse effects
No other adverse ecological effects identified.

13.1 Waste treatment methods
Waste Treatment Methods: Waste material must be disposed of in accordance with national and local regulations. Leave chemicals in original containers and do not mix with other waste. Handle uncleaned containers in the same manner as the product itself.

14.1 UN number
Not regulated as dangerous goods (research quantities typically exempt).

14.2 UN proper shipping name
Not subject to transport regulations (small quantities for research use).

14.3 Transport hazard class(es)
Not classified as dangerous goods for transport (research quantities).

14.4 Packing group
Not applicable (not regulated as dangerous goods in typical research quantities).

14.5 Environmental hazards
Marine pollutant: No (not classified as environmentally hazardous per GHS).

14.6 Special precautions for user
Transport in original packaging. Ensure containers are tightly sealed.
For bulk or commercial quantities, consult applicable transport regulations (DOT, IATA, IMDG).

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not applicable.

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
US EPA / TSCA: Subject to EPA TSCA regulations
EU ECHA / REACH: Registered (REACH Active)

SARA 302 Components:
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.
SARA 313 Components:
This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.
SARA 311/312 Hazards:
Acute (short-term) health hazard

Massachusetts Right To Know Components:
This material contains components subject to the Massachusetts Right to Know Act. See Section 2 for hazard classification.
Pennsylvania Right To Know Components:
This material contains components subject to the Pennsylvania Right to Know Act. See Section 2 for hazard classification.
New Jersey Right To Know Components:
This material contains components subject to the New Jersey Right to Know Act. See Section 2 for hazard classification.

California Prop. 65 Components:
This product does not contain any chemicals known to the State of California to cause cancer, birth defects, or any other reproductive harm.

Other regulatory listings:
- The Australian Inventory of Industrial Chemicals: Chemical: Phosphoric acid, disodium salt
- New Jersey Worker and Community Right to Know Act: The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)
- Clean Water Act Requirements: Sodium phosphate, dibasic is designated as a hazardous substance under section 311(b)(2)(A) of the Federal Water Pollution Control Act and further regulated by the Clean Water Act Amendments of 1977 and 1978. These regulations apply to discharges of this substance. This designation includes any isom
- CERCLA Reportable Quantities: Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 5000 lb or 2270 kg. The toll free number of the NRC is
- FIFRA Requirements: Residues of disodium phosphate are exempted from the requirement of a tolerance when used as a anticaking agent, conditioning agent in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops or to raw agricultural co

15.2 Chemical safety assessment
A chemical safety assessment has not been carried out for this substance.
For research-use-only compounds, no CSA is required under REACH Annex I.

Revision Date: 2026/09/09
Further Information: The information provided is believed to be correct but is not exhaustive and should be used only as a guideline based on current knowledge. It does not represent a guarantee of the properties of the product. Selleck Chemicals Corporation and its Affiliates shall not be held liable for any damage resulting from handling or contact with the product.