CAS No. 1577222-14-0
Batch:
Purity:99.98
Chemical Structure
Check the
Diroximel Fumarate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 1577222-14-0 | |
|---|---|---|
| Molecular Formula |
C11H13NO6 |
|
| Molecular Weight (MW) | 255.22 | |
| SMILES | COC(=O)C=CC(=O)OCCN1C(=O)CCC1=O |
Diroximel fumarate is a small-molecule prodrug that rapidly hydrolyzes to active monomethyl fumarate, a key activator of the Nrf2 signaling pathway. Upon conversion, monomethyl fumarate induces Nrf2 nuclear translocation and subsequently drives the expression of antioxidant response element-regulated cytoprotective genes. Consequently, this pathway activation enhances cellular defense against oxidative stress and attenuates downstream neuroinflammatory cascade responses.
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
51 mg/mL
(199.82 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 6 mg/mL |
| Water | 3 mg/mL |
| DMSO |
51 mg/mL
(199.82 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 9 mg/mL |
| Water | 4 mg/mL |
| DMSO |
51 mg/mL
(199.82 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.