CAS No. 537-67-7

Batch: Purity:99.92
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Diphenylamine Hydrochloride Chemical Structure
Chemical Structure
Check the Diphenylamine Hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-phenylaniline;hydrochloride
CAS Number 537-67-7
Molecular Formula

C12H12ClN
Molecular Weight (MW) 205.68
SMILES C1=CC=C(C=C1)NC2=CC=CC=C2.Cl
InChIKey JEFJSEIUEJBMSR-UHFFFAOYSA-N

Ordering Information

Biological Activity

Diphenylamine Hydrochloride is an aniline derivative that acts as an inhibitor of mitochondrial oxidative phosphorylation. By disrupting the mitochondrial bioenergetic machinery, it impairs ATP production and cellular energy metabolism. In addition to its impact on oxidative energy pathways, this compound exhibits antifungal and antihelmintic activities by altering essential cellular metabolic functions. These actions collectively suppress targeted fungal growth and cellular viability in biological systems. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 41 mg/mL (199.33 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.