CAS No. 68-12-2

DMF(N,N-Dimethylformamide) Chemical Structure
Chemical Structure
Check the DMF(N,N-Dimethylformamide) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 68-12-2
Molecular Formula

C3H7NO
Molecular Weight (MW) 73.09
SMILES CN(C)C=O

Biological Activity

DMF (N,N-Dimethylformamide) is a versatile polar aprotic solvent widely utilized as a solubilization vehicle in chemical synthesis and biochemical assays. In biological systems, DMF undergoes metabolic activation primarily mediated by cytochrome P450 enzymes such as CYP2E1, yielding reactive intermediates including N-hydroxymethyl-N-methylformamide. This metabolic pathway induces oxidative stress, alters cellular membrane integrity, and promotes hepatocyte injury, making DMF an important model compound in toxicological and biological studies.

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Note: Technical data last updated: Sep 1, 2026.