CAS No. 151358-48-4
Batch:
Purity:99.77
Chemical Structure
Check the
DIM-C-pPhCO2Me
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 151358-48-4 | |
|---|---|---|
| Molecular Formula |
C25H20N2O2 |
|
| Molecular Weight (MW) | 380.44 | |
| SMILES | COC(=O)C1=CC=C(C=C1)C(C2=CNC3=CC=CC=C32)C4=CNC5=CC=CC=C54 |
DIM-C-pPhCO2Me is a synthetic bis-indole derivative that acts as a selective antagonist of nuclear receptor 4A1 (NR4A1, also known as Nur77). Inhibition of NR4A1 by DIM-C-pPhCO2Me suppresses receptor-mediated transactivation, disrupts pro-survival pathway signaling, and induces apoptosis across multiple cancer cell lines. Consequently, this compound exhibits potent antineoplastic activity and serves as an effective chemical probe for evaluating NR4A1-dependent signaling mechanisms. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
76 mg/mL
(199.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 38 mg/mL |
| Water | Insoluble |
| DMSO |
76 mg/mL
(199.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.