CAS No. 444606-18-2
Batch:
Purity:99.86
Chemical Structure
Check the
Dilmapimod (SB-681323)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 8-(2,6-difluorophenyl)-2-(1,3-dihydroxypropan-2-ylamino)-4-(4-fluoro-2-methylphenyl)pyrido[2,3-d]pyrimidin-7-one | |
|---|---|---|
| CAS Number | 444606-18-2 | |
| Molecular Formula |
C23H19F3N4O3 |
|
| Molecular Weight (MW) | 456.42 | |
| SMILES | CC1=CC(=CC=C1C2=C3C=CC(=O)N(C3=NC(=N2)NC(CO)CO)C4=C(F)C=CC=C4F)F | |
| InChIKey | ORVNHOYNEHYKJG-UHFFFAOYSA-N |
Dilmapimod (SB-681323) is a potent inhibitor of p38 mitogen-activated protein kinase (MAPK). Inhibition of the p38 MAPK signaling pathway attenuates downstream inflammatory cascades by suppressing the phosphorylation of heat shock protein 27 (HSP27) and reducing the synthesis of pro-inflammatory cytokines, including tumor necrosis factor-alpha (TNF-α). Consequently, this blockade dampens cellular inflammatory responses and mitigates mediator release. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
91 mg/mL
(199.37 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 91 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.