CAS No. 6271-21-2
Batch:
Purity:99.46
Chemical Structure
Check the
Dihydrolycorine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (1S,15R,17S,18S,19R)-5,7-dioxa-12-azapentacyclo[10.6.1.02,10.04,8.015,19]nonadeca-2,4(8),9-triene-17,18-diol | |
|---|---|---|
| CAS Number | 6271-21-2 | |
| Molecular Formula |
C16H19NO4 |
|
| Molecular Weight (MW) | 289.33 | |
| SMILES | OC1CC2CCN3CC4=C(C=C5OCOC5=C4)C(C1O)C23 | |
| InChIKey | VJILFEGOWCJNIK-MGRBZGILSA-N |
Dihydrolycorine is an Amaryllidaceae alkaloid derivative of lycorine that acts as an inhibitor of protein synthesis. It blocks cellular protein translation in ascites cells and stabilizes polysomes in HeLa cells in vivo. Through the modulation of translational machinery and cellular stress pathways, dihydrolycorine exerts potent neuroprotective and antihypertensive activities in biological systems.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(345.62 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.